- ►diabetesjournals.org EP Blankenhorn, L Rodemich, C Martin-Fernandez, J … - Diabetes, 2005 - Am Diabetes Assoc BBDR rats develop autoimmune diabetes only after challenge with environmental
perturbants. These perturbants include polyinosinic:polycytidylic acid (poly I:C, a ligand of
toll-like receptor 3), agents that deplete regulatory T-cell (Treg) populations, and a non–β- ... Cited by 12 - Related articles - All 6 versions
- ►diabetesjournals.org RH Wallis, KS Wang, D Dabrowski, L Marandi, T Ning, … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—The biobreeding diabetes-prone (BBDP) rat spontaneously develops type 1
diabetes. Two of the genetic factors contributing to this syndrome are the major histocompatibility
complex (Iddm1) and a Gimap5 mutation (Iddm2) responsible for a T-lymphopenia. ... Cited by 2 - Related articles - BL Direct - All 7 versions
L HORNUM, D LUNDSGAARD, H … - ANNALS-NEW YORK …, 2007 - interscience.wiley.com Abstract : The Iddm4 gene controls diabetes in rats depleted of regulatory T cells (T reg ) and
immune-activated via treatment with the toll-like receptor 3 (TLR-3) ligand, polyI:C. Both
diabetes-resistant (BBDR) and diabetes-prone (BBDP) BB rats carry dominant permissive ... Cited by 3 - Related articles - BL Direct - All 4 versions
JP Mordes, L Cort, E Norowski, J Leif, JM Fuller, Å … - Mammalian Genome, 2009 - Springer Abstract Iddm14 (formerly Iddm4) is a non-MHC-linked genetic locus associated with autoimmune
diabetes. Its effects have been well-documented in BB-derived rats in which diabetes is either
induced by immunologic perturba- tion or occurs spontaneously. The role of Iddm14 in ... Cited by 4 - Related articles - All 2 versions
JP Mordes, J Leif, S Novak, C DeScipio, DL Greiner, … - Diabetes, 2002 - Am Diabetes Assoc Viral antibody–free BBDR and WF rats never develop spontaneous diabetes. BBDR rats,
however, develop autoimmune diabetes after perturbation of the immune system, eg, by viral
infection. We previously identified a disease-susceptibility locus in the BBDR rat, iddm4, ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org II Mendez, YH Chung, HS Jun, JW Yoon - The Journal of Immunology, 2004 - Am Assoc Immnol Macrophages play a critical role in the pathogenesis of Kilham rat virus (KRV)-induced autoimmune
diabetes in diabetes-resistant BioBreeding (DR-BB) rats. This investigation was initiated to determine
the role of macrophage-derived soluble mediators, particularly NO, in the pathogenesis of ... Cited by 9 - Related articles - BL Direct - All 4 versions
EP Blankenhorn, C DeScipio, L Rodemich, L … - Ann NY Acad …, 2007 - interscience.wiley.com Abstract : Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes
susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic
MHC-identical normal WF rats, Iddm4 d sensitively and specifically predicts induced ... Cited by 4 - Related articles - BL Direct - All 6 versions
L Hornum, C DeScipio, H Markholst, SA Troutman, S … - Mammalian Genome, 2004 - Springer 1 Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark 2 Department
of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane,
Philadelphia, Pennsylvania 19129, USA 3 Diabetes Division, University of Massachusetts ... Cited by 4 - Related articles - BL Direct - All 5 versions
JP Mordes, DL Guberski, JH Leif, BA Woda, JF … - Diabetes, 2005 - Am Diabetes Assoc We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility
complex congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1 u/u/a ) occurs with
a cumulative frequency of ∼2% at a median age of 59 days. The disease is characterized ... Cited by 10 - Related articles - BL Direct - All 6 versions
JM Fuller, AE Kwitek, TJ Hawkins, DH Moralejo, W Lu, … - Diabetes, 2006 - Am Diabetes Assoc Failure to express the Gimap5 protein is associated with lymphopenia (lyp) and linked to spontaneous
diabetes in the diabetes-prone BioBreeding (BBDP) rat. Gimap5 is a member of seven related
genes located within 150 Kb on rat chromosome 4. Congenic DR. lyp/lyp rats, where ... Cited by 6 - Related articles - BL Direct - All 5 versions
