MA Carvalho-Filho, M Ueno, SM Hirabara, AB Seabra, … - Diabetes, 2005 - Am Diabetes Assoc Evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible
nitric oxide synthase (iNOS) can induce insulin resistance in muscle. Here, we investigated whether
this insulin resistance could be mediated by S-nitrosation of proteins involved in early ... Cited by 58 - Related articles - All 6 versions
T Yasukawa, E Tokunaga, H Ota, H Sugita, JAJ … - Journal of Biological …, 2005 - ASBMB Inducible nitric-oxide synthase (iNOS) has been implicated in many human diseases including
insulin resistance. However, how iNOS causes or exacerbates insulin resistance remains largely
unknown. Protein S-nitrosylation is now recognized as a prototype of a redox-dependent, ... Cited by 55 - Related articles - All 5 versions
H Sugita, M Fujimoto, T Yasukawa, N Shimizu, M … - Journal of Biological …, 2005 - ASBMB Chronic inflammation plays an important role in insulin resistance. Inducible nitric-oxide synthase
(iNOS), a mediator of inflammation, has been implicated in many human diseases including
insulin resistance. However, the molecular mechanisms by which iNOS mediates insulin ... Cited by 35 - Related articles - All 5 versions
- ►physiology.org MA Carvalho-Filho, M Ueno, JBC … - American Journal of …, 2006 - Am Physiological Soc We have previously demonstrated that the insulin resistance associated with inducible nitric
oxide synthase (iNOS) induction in two different models of obesity, diet-induced obesity and
the ob/ob mice, is mediated by S-nitrosation of proteins involved in insulin signal ... Cited by 14 - Related articles - BL Direct - All 3 versions
M Perreault, A Marette - Nature medicine, 2001 - nature.com Inducible nitric oxide synthase (iNOS) is induced by inflammatory cytokines in skeletal muscle
and fat. It has been proposed that chronic iNOS induction may cause muscle insulin
resistance. Here we show that iNOS expression is increased in muscle and fat of genetic ... Cited by 189 - Related articles - BL Direct - All 4 versions
M Kaneki, N Shimizu, D Yamada, K … - Antioxidants & Redox …, 2007 - liebertonline.com I NSULIN RESISTANCE is a major causative factor for type 2 diabetes, which is a polygenic disease
accounting for >90% of patients with diabetes, and is associated with in- creased risk of cardiovascular
disease. Obesity is pandemic worldwide. Therefore, the pathogenesis of obesity-related ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Fujimoto, N Shimizu, K Kunii, JA Martyn, K Ueki, M … - Diabetes, 2005 - Am Diabetes Assoc Chronic inflammation has been postulated to play an important role in the pathogenesis of insulin
resistance. Inducible nitric oxide synthase (iNOS) has been implicated in many human diseases
associated with inflammation. iNOS deficiency was shown to prevent high-fat ... Cited by 24 - Related articles - All 5 versions
G Pilon, P Dallaire, A Marette - Journal of Biological Chemistry, 2004 - ASBMB AMP-activated protein kinase (AMPK), an energy-sensing enzyme that is activated in response
to cellular stress, is a critical signaling molecule for the regulation of multiple metabolic
processes. AMPK has recently emerged as an attractive novel target for the treatment of ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►physoc.org JR Pauli, ER Ropelle, DE Cintra, MA … - The Journal of …, 2008 - Physiological Soc Early evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible
nitric oxide synthase (iNOS) can induce insulin resistance. Here, we investigated whether this
insulin resistance, mediated by S-nitrosation of proteins involved in early steps of the ... Cited by 16 - Related articles - BL Direct - All 6 versions
ER Ropelle, JR Pauli, PO Prada, CT de … - The Journal of …, 2006 - Physiological Soc Lifestyle interventions including exercise programmes are cornerstones in the prevention of
obesity-related diabetes. In this study, we demonstrate that a single bout of exercise inhibits
high-fat diet-induced insulin resistance. Diet-induced obesity (DIO) increased the ... Cited by 35 - Related articles - BL Direct - All 8 versions
