- ►diabetesjournals.org S Srinivasan, M Ohsugi, Z Liu, S Fatrai, E … - Diabetes, 2005 - Am Diabetes Assoc An imbalance between the rate of protein synthesis and folding capacity of the
endoplasmic reticulum (ER) results in stress that has been increasingly
implicated in pancreatic islet β-cell apoptosis and diabetes. Because ... Cited by 48 - Related articles - All 5 versions
R Mussmann, M Geese, F Harder, S Kegel, U … - Journal of Biological Chemistry, 2007 - ASBMB Recent developments indicate that the regeneration of beta cell function and
mass in patients with diabetes is possible. A regenerative approach may
represent an alternative treatment option relative to current diabetes ... Cited by 30 - Related articles - All 7 versions
- ►jbc.org MJ Boucher, L Selander, L Carlsson, H … - Journal of Biological Chemistry, 2006 - ASBMB The transcription factor IPF1/PDX1 plays a crucial role in both pancreas
development and maintenance of -cell function. Targeted disruption of this
transcription factor in -cells leads to diabetes, whereas reduced ... Cited by 25 - Related articles - BL Direct - All 7 versions
M Ohsugi, C Cras-Meneur, Y Zhou, E Bernal- … - Journal of Biological Chemistry, 2005 - ASBMB Running Title: Multiple roles of insulin signaling in islet cells ... Reduced
Expression of the Insulin Receptor in Mouse Insulinoma (MIN6) Cells Reveals
Multiple Roles of Insulin Signaling in Gene Expression, Proliferation, ... Cited by 39 - Related articles - All 5 versions
SC Martinez, C Cras-Méneur, E Bernal- … - Diabetes, 2006 - Am Diabetes Assoc Glucose controls islet β-cell mass and function at least in part through the
phosphatidylinositol 3-kinase (PI3K)/Akt pathway downstream of insulin
signaling. The Foxo proteins, transcription factors known in other tissues ... Cited by 32 - Related articles - BL Direct - All 6 versions
Z Liu, K Tanabe, E Bernal-Mizrachi, MA … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Glycogen synthase kinase-3 (GSK3) has been implicated
in the pathophysiology of several prevalent diseases, including diabetes.
However, despite recent progress in our understanding of the role of GSK3 ... Cited by 12 - Related articles - BL Direct - All 3 versions
R Aikin, S Hanley, D Maysinger, M Lipsett, M … - Diabetologia, 2006 - Springer Page 1. ARTICLE Autocrine insulin action activates Akt and increases survival of
isolated human islets R. Aikin & S. Hanley & D. Maysinger & M. Lipsett & ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►nih.gov E Bernal-Mizrachi, W Wen, S Stahlhut, CM … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig The phosphoinositide 3-kinase–Akt/PKB pathway mediates the mitogenic effects
various nutrients and growth factors in cultured cells. To study its effects in
vivo in pancreatic islet β cells, we created transgenic mice that ... Cited by 167 - Related articles - BL Direct - All 9 versions
S Frame, D Zheleva - Expert Opin. Ther. Targets, 2006 - Informa Pharma Science The renewed interest in an enzyme first discovered over 25 years ago stems from
the potential of inhibitors of this enzyme to treat conditions as diverse as
diabetes, Alzheimer's disease, stroke and bipolar disorder, and even to ... Cited by 15 - Related articles - BL Direct - All 4 versions
JL Brewster, DA Linseman, RJ Bouchard, FA … - Molecular and Cellular Neuroscience, 2006 - Elsevier Loss of trophic or activity-dependent survival signals is commonly recognized as
a stimulus for neuronal apoptosis and may play a significant role in
neurodegeneration. Recent data have also implicated endoplasmic reticulum ... Cited by 20 - Related articles - All 3 versions
