D Porte, DG Baskin, MW Schwartz - Diabetes, 2005 - Am Diabetes Assoc Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing
the ingestion, distribution, metabolism, and storage of nutrients in organisms ranging from worms
to humans. Input from the environment regarding the availability and type of nutrients is ... Cited by 77 - Related articles - All 8 versions
D Porte Jr, DG Baskin, MW Schwartz - AGE, 2005 - Am Diabetes Assoc Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing
the inges- tion, distribution, metabolism, and storage of nutrients in organisms ranging from worms
to humans. Input from the environment regarding the availability and type of nutrients is ... Related articles
- ►kosen21.org [PDF] MW Schwartz, D Porte Jr - Science, 2005 - sciencemag.org Recent evidence suggests a key role for the brain in the control of both body fat content and glucose
metabolism. Neuronal systems that regulate energy intake, energy expenditure, and endogenous
glucose production sense and respond to input from hormonal and nutrient-related ... Cited by 268 - Related articles - All 12 versions
AP View - Springer This chapter reviews development of a concept first proposed by Dr. Stephen Woods and me
in 1976, that plasma insulin provides a critical feedback signal to the Central Nervous System
(CNS) for the biological regulation of body adiposity. It is a personal history and describes ... Related articles
- ►cell.com A Pocai, S Obici, GJ Schwartz, L Rossetti - Cell Metabolism, 2005 - Elsevier Increased glucose production (GP) is the major determinant of fasting hyperglycemia in diabetes
mellitus. Previous studies suggested that lipid metabolism within specific hypothalamic nuclei
is a biochemical sensor for nutrient availability that exerts negative feedback on GP. Here ... Cited by 97 - Related articles - All 9 versions
SC Woods, RJ Seeley, DG Baskin, MW … - Current pharmaceutical …, 2003 - ingentaconnect.com Abstract: Although several possible mechanisms exist by which the pancreatic hormone,
insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters
primarily by a receptor-mediated transport process. Many factors influence the rate of ... Cited by 85 - Related articles - BL Direct - All 3 versions
- ►nih.gov AW Xu, CB Kaelin, K Takeda, S Akira, MW … - Journal of Clinical …, 2005 - Am Soc Clin Investig Central control of energy balance depends on the ability of proopiomelanocortin (POMC) or
agouti-related protein (Agrp) hypothalamic neurons to sense and respond to changes in peripheral
energy stores. Leptin and insulin have been implicated as circulating indicators of ... Cited by 113 - Related articles - All 9 versions
- ►nih.gov L Plum, BF Belgardt, JC Brüning - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Insulin has pleiotropic biological effects in virtually all tissues. However, the relevance of insulin
signaling in peripheral tissues has been studied far more extensively than its role in the
brain. An evolving body of evidence indicates that in the brain, insulin is involved in ... Cited by 76 - Related articles - BL Direct - All 11 versions
D Porte Jr, DG Baskin, MW Schwartz - 糖尿病学杂志, 2005 - journal.shouxi.net Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing
the ingestion, distribution, metabolism, and storage of nutrients in organisms ranging from worms
to humans. Input from the environment regarding the availability and type of nutrients is ... Related articles - Cached
- ►nih.gov X Lin, A Taguchi, S Park, JA Kushner, F Li, … - Journal of Clinical …, 2004 - Am Soc Clin Investig The molecular link between obesity and β cell failure that causes diabetes is difficult to
establish. Here we show that a conditional knockout of insulin receptor substrate 2 (Irs2) in mouse
pancreas β cells and parts of the brain — including the hypothalamus —increased ... Cited by 117 - Related articles - BL Direct - All 11 versions
