- ►diabetesjournals.org SB Biddinger, K Almind, M Miyazaki, E … - Diabetes, 2005 - Am Diabetes Assoc Both environmental and genetic factors play important roles in the development
of the metabolic syndrome. To elucidate how these factors interact under normal
conditions, C57Bl/6 (B6) and 129S6/SvEvTac (129) mice were placed on a ... Cited by 70 - Related articles - All 7 versions
- ►shouxi.net SB Biddinger, M Miyazaki, J Boucher, JM … - Diabetes, 2006 - Am Diabetes Assoc Stearoyl-CoA desaturase (SCD)1 catalyzes the rate-limiting reaction of
monounsaturated fatty acid (MUFA) synthesis and plays an important role in the
development of obesity. SCD1 is suppressed by leptin but induced by ... Cited by 18 - Related articles - BL Direct - All 5 versions
CC Hu, K Qing, Y Chen - Obesity research, 2004 - cat.inist.fr Objective: To investigate stearoyl-coenzyme A desaturase(SCD) 1 expression in
obesity-prone C 57 BL/6 mice and in obesity-resistant FVB mice to explore the
relationship of SCD 1 expression and susceptibility to diet-inducedobesity. ... Cited by 30 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org K Almind, CR Kahn - Diabetes, 2004 - Am Diabetes Assoc Diet-induced obesity is the primary determinant of the current epidemic of
diabetes. We have explored the role of genetics in this phenomenon, using
C57Bl/6 (B6), 129S6/SvEvTac (129), and intercross (B6 × 129)F2 mice on a ... Cited by 52 - Related articles - BL Direct - All 6 versions
- ►physiology.org JH Hwang, DT Stein, N Barzilai, MH Cui, J … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc Recent studies have indicated that the mass/content of intramyocellular lipid
(IMCL), intrahepatic triglyceride (IHTG), visceral fat (VF), and even deep
abdominal subcutaneous fat (SF) may all be correlated with insulin ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►jbc.org H Sampath, M Miyazaki, A Dobrzyn, JM … - Journal of Biological Chemistry, 2007 - ASBMB Dietary saturated fats have often been implicated in the promotion of obesity
and related disorders. It has been shown recently that saturated fats act
through the transcription factor SREBP-1c (sterol regulatory ... Cited by 40 - Related articles - All 8 versions
- ►nih.gov R Gutiérrez-Juárez, A Pocai, C Mulas, H Ono, … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Stearoyl-CoA desaturase–1 (SCD1) catalyzes the synthesis of monounsaturated
fatty acids from saturated fatty acids. Mice with a targeted disruption of Scd1
gene locus are lean and display increased insulin sensitivity. To examine ... Cited by 69 - Related articles - BL Direct - All 7 versions
- ►nih.gov G Jiang, Z Li, F Liu, K Ellsworth, Q Dallas- … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Effective therapies for the treatment of obesity, a key element of metabolic
syndrome, are urgently needed but currently lacking. Stearoyl-CoA desaturase–1
(SCD1) is the rate-limiting enzyme catalyzing the conversion of saturated ... Cited by 83 - Related articles - All 11 versions
PI Parekh, AE Petro, JM Tiller, MN Feinglos, … - Metabolism, 1998 - Elsevier We have previously shown that C57BL/6J (B6) mice develop severe obesity and
diabetes if weaned onto high-fat diets, whereas A/J mice tend to be obesity and
diabetes-resistant. The purpose of this study was to determine if obesity ... Cited by 62 - Related articles - BL Direct - All 6 versions
SB Biddinger, A Hernandez-Ono, C Rask- … - Cell metabolism, 2008 - Elsevier Insulin resistance plays a central role in the development of the metabolic
syndrome, but how it relates to cardiovascular disease remains controversial.
Liver insulin receptor knockout (LIRKO) mice have pure hepatic insulin ... Cited by 37 - Related articles - All 5 versions
