- ►diabetesjournals.org M Fujimoto, N Shimizu, K Kunii, JA Martyn, K Ueki, M … - Diabetes, 2005 - Am Diabetes Assoc Chronic inflammation has been postulated to play an important role in the pathogenesis of insulin
resistance. Inducible nitric oxide synthase (iNOS) has been implicated in many human diseases
associated with inflammation. iNOS deficiency was shown to prevent high-fat ... Cited by 24 - Related articles - All 5 versions
H Sugita, M Fujimoto, T Yasukawa, N Shimizu, M … - Journal of Biological …, 2005 - ASBMB Chronic inflammation plays an important role in insulin resistance. Inducible nitric-oxide synthase
(iNOS), a mediator of inflammation, has been implicated in many human diseases including
insulin resistance. However, the molecular mechanisms by which iNOS mediates insulin ... Cited by 35 - Related articles - All 5 versions
- ►endojournals.org K Tsuchiya, H Sakai, N Suzuki, F Iwashima, T … - Endocrinology, 2007 - Endocrine Soc Genetic deletion of inducible nitric oxide synthase (NOS) in mice has been shown to improve
high-fat diet (HFD)-induced insulin resistance. However, a pathophysiological role of endogenous
nitric oxide (NO) in obesity-related insulin resistance remains controversial. To address ... Cited by 14 - Related articles - BL Direct - All 3 versions
T Yasukawa, E Tokunaga, H Ota, H Sugita, JAJ … - Journal of Biological …, 2005 - ASBMB Inducible nitric-oxide synthase (iNOS) has been implicated in many human diseases including
insulin resistance. However, how iNOS causes or exacerbates insulin resistance remains largely
unknown. Protein S-nitrosylation is now recognized as a prototype of a redox-dependent, ... Cited by 55 - Related articles - All 5 versions
SE Cohen, YH Tseng, MD Michael, CR Kahn - Diabetologia, 2004 - Springer Aims/hypothesis. The metabolic abnormalities of insu- lin resistance are ameliorated by insulin
sensitisers via different mechanisms. Metformin decreases hepatic glucose output, whereas
rosiglitazone (RSG) is an ag- onist for peroxisome proliferator activated receptor (PPAR)γ, ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org [PDF] SH Torres, JB De Sanctis, LM de Briceno, N … - Journal of …, 2004 - Soc Endocrinology An inflammatory process may be involved in nitric oxide production in skeletal muscle of type
2 diabetic patients. Nitric oxide generation in skeletal muscle was assessed in 14 non-complicated
type 2 diabetic patients and in 12 healthy subjects. In samples of quadriceps femoris ... Cited by 41 - Related articles - BL Direct - All 6 versions
G Pilon, P Dallaire, A Marette - Journal of Biological Chemistry, 2004 - ASBMB AMP-activated protein kinase (AMPK), an energy-sensing enzyme that is activated in response
to cellular stress, is a critical signaling molecule for the regulation of multiple metabolic
processes. AMPK has recently emerged as an attractive novel target for the treatment of ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►jlr.org S Engeli, J Janke, K Gorzelniak, J Bohnke, N … - The Journal of Lipid …, 2004 - ASBMB Nitric oxide (NO) is involved in adipose tissue biology by influencing adipogenesis, insulin-stimulated
glucose uptake, and lipolysis. The enzymes responsible for NO formation in adipose cells are
endothelial NO synthase (eNOS) and inducible NO synthase (iNOS), whereas neuronal ... Cited by 35 - Related articles - BL Direct - All 5 versions
- ►physiology.org H Sugita, M Kaneki, E Tokunaga, M Sugita … - American Journal of …, 2002 - Am Physiological Soc The molecular mechanisms underlying endotoxin-induced insulin resistance remain
unclear. Endotoxin or lipopolysaccharide (LPS) injection is a potent stimulator of inducible nitric
oxide synthase (iNOS). This study in rats, using the specific iNOS inhibitor ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org P Dallaire, K Bellmann, M Laplante, S Gélinas, C … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Rosiglitazone was found to similarly improve whole-body insulin sensitivity and
insulin signaling to Akt/PKB in skeletal muscle of obese iNOS –/– and obese iNOS +/+ mice.
However, rosiglitazone further improved glucose tolerance and liver insulin signaling only ... Cited by 3 - Related articles - All 4 versions
