R Andrew, J Westerbacka, J Wahren, H Yki-Järvinen, … - Diabetes, 2005 - Am Diabetes Assoc Cortisol is regenerated from cortisone by 11β-hydroxysteroid dehydrogenase type 1
(11HSD1), amplifying glucocorticoid action in adipose tissue and liver. 11HSD1 inhibitors are
being developed for type 2 diabetes and may be most effective in obesity, where adipose ... Cited by 55 - Related articles - All 6 versions
- ►diabetesjournals.org TC Sandeep, R Andrew, NZM Homer, RC Andrews, K … - Diabetes, 2005 - Am Diabetes Assoc 11ß-Hydroxysteroid dehydrogenase type 1 (11HSD1) regenerates cortisol from cortisone within
adipose tissue and liver. 11HSD1 inhibitors may enhance insulin sensitivity in type 2 diabetes
and be most efficacious in obesity when 11HSD1 is increased in subcutaneous adipose ... Cited by 67 - Related articles - All 8 versions
- ►endojournals.org R Andrew, K Smith, GC Jones, BR Walker - Journal of Clinical …, 2002 - Endocrine Soc We have investigated the use of [9,11,12,12- 2 H 4 ]cortisol (d4F) to distinguish the dehydrogenase
and reductase activities. On metabolism by dehydrogenation, d4F loses 11 - deuterium, forming
trideuterated cortisone (d3E) and is regenerated by reduction to trideuterated cortisol ... Cited by 43 - Related articles - BL Direct - All 6 versions
R Basu, RJ Singh, A Basu, EG Chittilapilly, CM … - Diabetes, 2004 - ncbi.nlm.nih.gov Glucocorticoids are potent regulators of protein, fat, and carbohydrate metabolism. To determine
if cortisol production occurs within the splanchnic bed in humans, 11 nondiabetic subjects were
studied using the hepatic/leg catheterization method along with an infusion of [9,11,12,12- ... Cited by 36 - Related articles - BL Direct - All 2 versions
W Aldhahi, E Mun, AB Goldfine - Diabetologia, 2004 - Springer Aims/hypothesis. Excess total body and visceral fat has been associated with insulin
resistance, diabetes and the metabolic syndrome. Excess glucocorticoids produce both central
obesity and diabetes. However, systemic glucocorticoid levels are normal in typical Type ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►endojournals.org NM Morton, L Ramage, JR Seckl - Endocrinology, 2004 - Endocrine Soc The enzyme 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1) amplifies intracellular glucocorticoid
action in vivo. 11ß-HSD-1 activity is increased in adipose tissues of obese humans and genetically
obese rodents, providing a mechanistic basis for the similarities between metabolic ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►endojournals.org K Kannisto, KH Pietilainen, E Ehrenborg, A … - Journal of Clinical …, 2004 - Endocrine Soc 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD-1) catalyzes the interconversion of inactive
cortisone to active cortisol. Overexpression of 11ß-HSD-1 in murine adipose tissue results in
glucocorticoid receptor (GR) overexpression, central obesity, and insulin resistance. It is ... Cited by 104 - Related articles - BL Direct - All 7 versions
[CITATION] Splanchnic cortisol production occurs in humans: evidence for conversion of …
BR Walker - Diabetologia, 2004 - Springer Adipose tissue is increasingly recognised as an “endo- crine factory”, releasing many newly
identified hor- mones such as leptin, resistin, adiponectin etc. These discoveries have stirred
enthusiasm for investigating “older” hormones that are also released from adipose tissue. ... Cited by 10 - Related articles - BL Direct - All 3 versions
