S You, M Belghith, S Cobbold, MA Alyanakian, C … - Diabetes, 2005 - Am Diabetes Assoc Diabetogenic T-cells can be detected in pre-diabetic nonobese diabetic (NOD) mice after transfer in
NOD-SCID recipients. Here we demonstrate that 6-week-old pre-diabetic NOD mice, >2 months before
disease onset, already harbor ... Cited by 97 - Related articles - All 5 versions
- ►jimmunol.org S Gregori, N Giarratana, S Smiroldo, L … - The Journal of …, 2003 - Am Assoc Immnol In the nonobese diabetic (NOD) mouse, pathogenic and suppressor CD4 + T cells can be distinguished
by the constitutive expression of CD25. In this study, we demonstrate that the progression of
autoimmune diabetes in NOD mice ... Cited by 126 - Related articles - BL Direct - All 4 versions
- ►rupress.org SM Pop, CP Wong, DA Culton, SH Clarke, R … - Journal of Experimental …, 2005 - jem.rupress.org Natural CD4 + CD25 + regulatory T (CD4 + CD25 + T reg) cells play a key role in the immunoregulation
of autoimmunity. However, little is known about the interactions between CD4 + CD25 + T reg cells
and autoreactive T cells. This is ... Cited by 113 - Related articles - All 8 versions
- ►rupress.org Z Chen, AE Herman, M Matos, D Mathis, C … - Journal of Experimental …, 2005 - jem.rupress.org Foxp3 is required for the generation and activity of CD4 + CD25 + regulatory T (T reg) cells, which
are important controllers of autoimmunity, including type-1 diabetes. To determine where T reg cells
affect the diabetogenic cascade, we ... Cited by 103 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org TM Brusko, CH Wasserfall, MJ Clare-Salzler, DA … - Diabetes, 2005 - Am Diabetes Assoc CD4 + CD25 + T-cells appear to play a crucial role in regulating the immune response. Therefore, we
evaluated the peripheral blood frequency and function of CD4 + CD25 + T-cells in 70 type 1 diabetic
patients and 37 healthy ... Cited by 110 - Related articles - All 5 versions
- ►202.201.6.125 [PDF] MS Anderson, JA Bluestone - 2004 - Annual Reviews ▪ Abstract Autoimmunity is a complex process that likely results from the summation of multiple
defective tolerance mechanisms. The NOD mouse strain is an excellent model of autoimmune disease and
an important tool for dissecting ... Cited by 266 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org RK Gregg, R Jain, SJ Schoenleber, R … - The Journal of …, 2004 - Am Assoc Immnol Autoimmunity presumably manifests as a consequence of a shortfall in the maintenance of peripheral
tolerance by CD4 + CD25 + T regulatory cells (Tregs). However, the mechanism underlying the
functional impairment of Tregs ... Cited by 60 - Related articles - All 6 versions
- ►diabetesjournals.org M Tritt, E Sgouroudis, E d'Hennezel, A Albanese, CA … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We show that the cellular frequency of Foxp3 + nT reg cells in primary and secondary
lymphoid tissues is stable and does not decline relative to type 1 diabetes–resistant mice. We
show that thymic and peripheral CD4 ... Cited by 33 - Related articles - BL Direct - All 5 versions
AL Putnam, F Vendrame, F Dotta, PA Gottlieb - Journal of Autoimmunity, 2005 - Elsevier In mouse models, CD4 + CD25 + T cells are involved in maintenance of peripheral tolerance. In
humans, a subset of CD4 + CD25 + T cells expressing high levels of CD25 (CD4 + CD25 high ) with
characteristics identical to murine ... Cited by 75 - Related articles - All 3 versions
- ►nih.gov Q Tang, JY Adams, C Penaranda, K Melli, E Piaggio, E … - Immunity, 2008 - Elsevier The dynamics of CD4 + effector T cells (Teff cells) and CD4 + Foxp3 + regulatory T cells (Treg
cells) during diabetes progression in nonobese diabetic mice was investigated to determine whether
an imbalance of Treg cells and Teff ... Cited by 55 - Related articles - All 7 versions
