- ►diabetesjournals.org H Chen, X Li, PN Epstein - Diabetes, 2005 - Am Diabetes Assoc Reactive oxygen species (ROS) and nitric oxide (NO) are proposed mediators of cytokine-induced
β-cell destruction in type 1 diabetes. We produced transgenic mice with increased β-cell expression
of manganese superoxide dismutase (MnSOD) and catalase. Expression of these ... Cited by 34 - Related articles - All 6 versions
J Sandström, LM Jonsson, H Edlund, D Holmberg, … - Free Radical Biology and …, 2002 - Elsevier Mice of the nonobese diabetic strain develop a progressive insulitis resulting in beta-cell destruction
and diabetes. Superoxide radicals are abundantly formed by leukocytes and other mechanisms
in inflammatory reactions. We here aimed to determine whether superoxide radicals ... Cited by 9 - Related articles - BL Direct - All 4 versions
X Li, H Chen, PN Epstein - Diabetes, 2006 - Am Diabetes Assoc It is widely proposed that reactive oxygen species (ROS) contribute to β-cell death in type 1
diabetes. We tested this in nonobese diabetic (NOD) mice using β-cell–specific overexpression
of three antioxidant proteins: metallothionein (MT), catalase (Cat), or manganese ... Cited by 15 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] G Papaccio, F Nicoletti, FA Pisanti, M Galdieri, … - Molecular …, 2002 - pubmedcentral.nih.gov 1 Department of Experimental Medicine, Laboratory of Histology and Embryology, School of
Medicine, 2nd University of Naples, Naples 2 Department of Biomedical Sciences, Section of
General Pathology, University of Catania, Catania 3 Department of Cell Biology, School ... Cited by 17 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org T Tabatabaie, A Vasquez-Weldon, DR Moore, Y Kotake - Diabetes, 2003 - Am Diabetes Assoc Free radical formation evoked by proinflammatory cytokines has been suggested to be involved
in the destruction of β-cells in the course of type 1 diabetes development. However, there is no
direct evidence to support this hypothesis. In this study, we used electron paramagnetic ... Cited by 40 - Related articles - BL Direct - All 4 versions
X Li, H Chen, PN Epstein - Journal of Biological Chemistry, 2004 - ASBMB Islet transplantation is a promising therapy for Type 1 diabetes, but many attempts have failed
due to early graft hypoxia or immune rejection, which generate reactive oxygen species
(ROS). In the current study, we determined that transgenic overexpression of the ... Cited by 66 - Related articles - BL Direct - All 5 versions
S Bertera, ML Crawford, AM Alexander, GD Papworth, … - Diabetes, 2003 - Am Diabetes Assoc Islet transplantation is a promising cure for diabetes. However, inflammation, allorejection, and
recurrent autoimmune damage all may contribute to early graft loss. Pancreatic islets express
lower levels of antioxidant genes than most other tissues of the body, and β-cells in ... Cited by 68 - Related articles - BL Direct - All 4 versions
J Irie, A Shimada, Y Oikawa, T Shigihara, T Saruta - Diabetologia, 2004 - Springer Aims/hypothesis. Type 1 diabetes mellitus is caused by autoimmune pancreatic beta cell
destruction, and the destructive process involves several molecular mecha- nisms including
oxygen-reactive species. A cysteine derivative, N-acetyl-cysteine, is widely used as an ... Cited by 5 - Related articles - BL Direct - All 4 versions
S Lortz, M Tiedge, T Nachtwey, AE Karlsen, J … - DIABETES-NEW …, 2000 - Am Diabetes Assoc Nitric oxide (NO) and reactive oxygen species (ROS) are crucial elements in cytokine-mediated
-cell destruc- tion. In insulin-producing RINm5F cells, overexpression of cytoprotective enzymes
provides significant protection against the synergistic toxicity of NO and ROS. We ... Cited by 126 - Related articles - BL Direct - All 4 versions
TB Mysore, TA Shinkel, J Collins, EJ Salvaris, N … - Diabetes, 2005 - Am Diabetes Assoc Primary nonfunction of transplanted islets results in part from their sensitivity to reactive oxygen
species (ROS) generated during the isolation and transplantation process. Our aim was to examine
whether coexpression of antioxidant enzymes to detoxify multiple ROS increased the ... Cited by 27 - Related articles - All 5 versions
