- ►diabetesjournals.org HKR Karlsson, K Hällsten, M Björnholm, H Tsuchida, … - Diabetes, 2005 - Am Diabetes Assoc The effect of metformin or rosiglitazone monotherapy versus placebo on insulin signaling and
gene expression in skeletal muscle of patients with newly diagnosed type 2 diabetes was
determined. A euglycemic-hyperinsulinemic clamp, combined with skeletal muscle ... Cited by 34 - Related articles - All 6 versions
HKR Karlsson, JR Zierath, S Kane, A Krook, GE … - Diabetes, 2005 - Am Diabetes Assoc AS160 is a newly described substrate for the protein kinase Akt that links insulin signaling and
GLUT4 trafficking. In this study, we determined the expression of and in vivo insulin action on
AS160 in human skeletal muscle. In addition, we compared the effect of physiological ... Cited by 78 - Related articles - All 5 versions
HJ Herr, JR Bernard, DW Reeder, DA Rivas, … - The Journal of …, 2005 - Physiological Soc Several recent reports using cell lines have suggested that both Akt and atypical protein kinase
C (aPKC) ζ/λ are translocated to the plasma membrane (PM) in response to insulin.
However, it has yet to be determined in skeletal muscle whether: (1) insulin increases PM- ... Cited by 5 - Related articles - All 7 versions
Y Miyazaki, H He, LJ Mandarino, RA DeFronzo - Diabetes, 2003 - Am Diabetes Assoc Thiazolidinediones (TZDs) improve glycemic control and insulin sensitivity in patients with type
2 diabetes. To determine whether the TZD-induced improvement in glycemic control is associated
with enhanced insulin receptor signaling in skeletal muscle, 20 type 2 diabetic patients ... Cited by 74 - Related articles - BL Direct - All 8 versions
CP Mîinea, H Sano, S Kane, E Sano, M … - Biochemical …, 2005 - pubmedcentral.nih.gov Recently, we described a 160 kDa protein (designated AS160, for Akt substrate of 160 kDa) with
a predicted Rab GAP (GTPase-activating protein) domain that is phosphorylated on multiple
sites by the protein kinase Akt. Phosphorylation of AS160 in adipocytes is required for ... Cited by 88 - Related articles - BL Direct - All 7 versions
MD Bruss, EB Arias, GE Lienhard, GD Cartee - Diabetes, 2005 - Am Diabetes Assoc In 3T3-L1 adipocytes, insulin-stimulated GLUT4 translocation requires phosphorylation of the
protein designated Akt substrate of 160 kDa (AS160). Both insulin and contractions activate Akt
in skeletal muscle. Therefore, we assessed the effects in skeletal muscle of each stimulus ... Cited by 102 - Related articles - All 8 versions
- ►diabetesjournals.org HKR Karlsson, M Ahlsén, JR Zierath, H Wallberg- … - Diabetes, 2006 - Am Diabetes Assoc Aberrant insulin signaling and glucose metabolism in skeletal muscle from type 2 diabetic patients
may arise from genetic defects and an altered metabolic milieu. We determined insulin action
on signal transduction and glucose transport in isolated vastus lateralis skeletal muscle ... Cited by 26 - Related articles - BL Direct - All 5 versions
SE Borst, HG Snellen, HL Lai - Life Sciences, 2000 - Elsevier Although the glucose-lowering properties of metformin are well-established, its effects on glucose
metabolism in skeletal muscle have not been clearly defined. We tested the effects of metformin
in young adult male Sprague-Dawley rats, which have a documented reduced response ... Cited by 11 - Related articles - BL Direct - All 3 versions
MM Meyer, K Levin, T Grimmsmann, N Perwitz, A Eirich … - Diabetes, 2002 - Am Diabetes Assoc We investigated whether the effect of troglitazone on glucose disposal is associated with altered
insulin signaling. Nondiabetic first-degree relatives of type 2 diabetic patients (age 30 ± 2
years, BMI 30 ± 1 kg/m 2 ; n = 20) were randomized in a double-blind manner to 3 months ... Cited by 28 - Related articles - BL Direct - All 4 versions
M Larance, G Ramm, J Stöckli, EM van Dam, S … - Journal of Biological …, 2005 - ASBMB Insulin stimulates the translocation of the glucose transporter GLUT4 from intracellular vesicles
to the plasma membrane. In the present study we have conducted a comprehensive proteomic
analysis of affinity-purified GLUT4 vesicles from 3T3-L1 adipocytes to discover potential ... Cited by 111 - Related articles - BL Direct - All 6 versions
