GJS Cooper, YK Chan, AM Dissanayake, FE … - Diabetes, 2005 - Am Diabetes Assoc We recently showed that treatment with the Cu II -selective chelator, trientine,
alleviates heart failure in diabetic rats, improves left ventricular hypertrophy
in humans with type 2 diabetes, and increases urinary Cu excretion in both ... Cited by 28 - Related articles - All 9 versions
GJS Cooper, ARJ Phillips, SY Choong, BL … - Diabetes, 2004 - Am Diabetes Assoc Heart disease is the major cause of death in diabetes, a disorder characterized
by chronic hyperglycemia and cardiovascular complications. Although altered
systemic regulation of transition metals in diabetes has been the subject ... Cited by 49 - Related articles - BL Direct - All 8 versions
- ►aspetjournals.org D Gong, J Lu, X Chen, SY Choong, S Zhang, … - Molecular pharmacology, 2006 - ASPET Most patients with diabetes die from cardiac or arterial disease, for which
there are limited therapeutic options. Free Cu 2+ ions are strongly pro-oxidant,
and chelatable-Cu II is increased in the diabetic heart. We reported ... Cited by 10 - Related articles - All 6 versions
H Kodama, Y Murata, T Iitsuka, T Abe - Life Sciences, 1997 - Elsevier Triethylene tetramine dihydrochloride (trien 2HC1) has been used for the
treatment of Wilson's disease, which is characterized by the accumulation of
copper in various organs. We previously developed an HPLC system for ... Cited by 31 - Related articles - BL Direct - All 5 versions
H KODAMA, Y MEGURO, A TSUNAKAWA, Y … - The Tohoku Journal of Experimental Medicine, 1993 - Journal@rchive MURAKITA, H. Fate of Orally Administered Triethylenetetramine Dihydrochloride :
A Therapeutic Drug for Wilson's Disease. Tohoku J. Exp. Med., 1993, 169 (1), 59-
66 Triethylenetetramine dihydrochloride (TETA) is a therapeutic drug for ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org J Lu, YK Chan, GD Gamble, SD Poppitt, AA … - Drug Metabolism and Disposition, 2007 - ASPET Triethylenetetramine (TETA), a selective Cu II -chelator used in the treatment
of Wilson's disease, is now undergoing clinical trials for the treatment of
heart failure in diabetes. Despite decades of clinical use, knowledge of ... Cited by 8 - Related articles - BL Direct - All 6 versions
A HortResearch, N Zealand - PROTEOMICS - interscience.wiley.com Cardiac disease is the commonest cause of death amongst diabetic patients.
Diabetic cardiomyopathy, which has a poor prognosis, is characterized by left
ventricular hypertrophy and impaired cardiac function and mitochondrial ... Cited by 5 - Related articles - BL Direct
R Tanabe, M Kobayashi, M Sugawara, K Iseki, … - The Journal of pharmacy and pharmacology, 1996 - ncbi.nlm.nih.gov The uptake characteristics of trientine by rat intestinal brush-border membrane
vesicles were studied. The uptake characteristics of trientine were similar to
those of the physiological polyamines with respect to the excessive ... Cited by 9 - Related articles - BL Direct - All 2 versions
Y Nakano, H Nohta, H Yoshida, T Saita, H … - Journal of Chromatography B, 2002 - Elsevier A highly selective and simple fluorimetric liquid chromatographic method for the
determination of triethylenetetramine (TETA), a therapeutic drug for Wilson's
disease, in human and rabbit sera is described. This method is based on ... Cited by 22 - Related articles - All 3 versions
