- ►diabetesjournals.org F Li, VR Drel, C Szabó, MJ Stevens, IG … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) inhibition has recently been identified as a
novel approach to treatment of experimental peripheral diabetic neuropathy
(PDN). However, long-term inhibition of PARP, an enzyme involved in DNA ... Cited by 25 - Related articles - All 5 versions
- ►nih.gov IG Obrosova, VR Drel, P Pacher, O Ilnytska, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the
pathogenesis of diabetes complications, is considered a downstream effector of
oxidative-nitrosative stress. However, some recent findings suggest that it ... Cited by 37 - Related articles - BL Direct - All 11 versions
- ►physiology.org F Li, IG Obrosova, O Abatan, D Tian, D Larkin … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc The etiology of painful diabetic neuropathy is poorly understood, but may result
from neuronal hyperexcitability secondary to alterations of Ca 2+ signaling in
sensory neurons. The naturally occurring amino acid taurine functions as an ... Cited by 34 - Related articles - All 4 versions
IG Obrosova, F Li, OI Abatan, MA Forsell, K … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic
neuropathy, but the mechanisms remain unidentified. Here we provide evidence
that poly(ADP-ribose) polymerase (PARP) activation, a downstream effector ... Cited by 87 - Related articles - BL Direct - All 10 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and
high-energy phosphates, activates protein kinase C, and affects gene expression
in various tissues. This study was designed to charac- terise the effects ... Cited by 38 - Related articles - BL Direct - All 11 versions
NE Cameron, Z Tuck, L McCabe, MA Cotter - Diabetologia, 2001 - Springer Page 1. Oxidative stress contributes to the neural and vascu- lar complications
of diabetes [1, 2]. For nerve, antiox- idant protection ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►nih.gov O Ilnytska, VV Lyzogubov, MJ Stevens, VR … - Diabetes, 2006 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental
mechanism in the pathogenesis of diabetes complications including diabetic
neuropathy. This study evaluated the role of PARP in diabetic sensory ... Cited by 26 - Related articles - BL Direct - All 10 versions
- ►nih.gov IG Obrosova, P Pacher, C Szabó, Z … - Diabetes, 2005 - Am Diabetes Assoc This study evaluated the effects of aldose reductase inhibition on
diabetes-induced oxidative-nitrosative stress and poly(ADP-ribose) polymerase
(PARP) activation. In animal experiments, control and ... Cited by 73 - Related articles - All 8 versions
- ►aspetjournals.org MJ Stevens, F Li, VR Drel, OI Abatan, H Kim, … - Journal of Pharmacology and Experimental …, 2007 - ASPET In diabetes, activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP)
is an important effector of oxidative-nitrosative injury, which contributes to
the development of experimental diabetic peripheral neuropathy (DPN). ... Cited by 21 - Related articles - All 7 versions
L Hounsom, R Corder, J Patel, DR Tomlinson - Diabetologia, 2001 - Springer Oxidative stress has been suggested to be a causal factor of diabetic
complications [1±3]. Diabetes com- promises natural antioxidant defence
systems, lower- ing tissue GSH (reduced glutathione), ascorbic acid, ... Cited by 31 - Related articles - BL Direct - All 5 versions
