JK Krady, A Basu, CM Allen, Y Xu, KF LaNoue, TW … - Diabetes, 2005 - Am Diabetes Assoc Diabetes leads to vascular leakage, glial dysfunction, and neuronal apoptosis within the
retina. The goal of the studies reported here was to determine the role that retinal microglial cells
play in diabetic retinopathy and assess whether minocycline can decrease microglial ... Cited by 81 - Related articles - All 10 versions
XXIA ZENG, YEEK NG, ENGANG LING - Visual Neuroscience, 2000 - Cambridge Univ Press Abstract This study reports Müller cell and neuronal changes and microglial reaction in
streptozotocin-induced diabetic rats. Glial fibrillary acidic protein (GFAP) immunoreactivity was
largely confined to astrocytes in the nerve fiber layer (NFL) and ganglion cell layer (GCL) ... Cited by 73 - Related articles - BL Direct - All 3 versions
- ►iovs.org E Rungger-Brandle, AA Dosso, PM Leuenberger - Investigative ophthalmology & …, 2000 - ARVO METHODS. Rats were rendered diabetic by streptozotocin injection and killed after 2, 4, 12, or
20 weeks. Cell densities were determined in flatmounted retinas or transverse semithin
sections. Expression of glial fibrillary acidic protein (GFAP) was localized on frozen ... Cited by 146 - Related articles - BL Direct - All 3 versions
JA Vincent, S Mohr - Diabetes, 2007 - Am Diabetes Assoc The proinflammatory cytokine, interleukin (IL)-1β, is known to induce vascular dysfunction and
cell death. We investigated the role of IL-1β and caspase-1 (the enzyme that produces it) in
diabetes-induced degeneration of retinal capillaries. Caspase-1 activity is increased in ... Cited by 19 - Related articles - BL Direct - All 5 versions
S Mohr, X Xi, J Tang, TS Kern - Diabetes, 2002 - Am Diabetes Assoc Apoptosis of retinal capillary cells begins early in diabetes and likely contributes to the capillary
obliteration that is an important feature of diabetic retinopathy. Caspases are proteolytic enzymes
that are closely involved in the induction and execution phases of apoptosis, but their role ... Cited by 82 - Related articles - BL Direct - All 4 versions
C Gerhardinger, MB Costa, MC Coulombe, I Toth, T … - … ophthalmology & visual …, 2005 - ARVO RESULTS. Gene expression profiling identified 78 genes as differentially expressed in diabetic
Müller cells. One third of these genes were associated with inflammation, including a large cluster
(18% of the differentially expressed genes) of acute-phase response proteins: 2 - ... Cited by 75 - Related articles - All 6 versions
DA Antonetti, AJ Barber, SK Bronson, WM Freeman, … - Diabetes, 2006 - Am Diabetes Assoc Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians. Destruction
of damaged retina by photocoagulation remains the primary treatment nearly 50 years after its
introduction. The diabetes pandemic requires new approaches to understand the ... Cited by 73 - Related articles - BL Direct - All 9 versions
- ►iovs.org AJ Barber, DA Antonetti, TS Kern, CEN Reiter, RS … - … ophthalmology & visual …, 2005 - ARVO RESULTS. The mean blood glucose of Ins2 Akita mice was significantly elevated, whereas the
body weight at death was reduced compared with that of control animals. Compared with sibling
control mice, the Ins2 Akita mice had increased retinal vascular permeability after 12 ... Cited by 61 - Related articles - All 4 versions
- ►fasebj.org [PDF] AM Joussen, V Poulaki, ML Le, K Koizumi, C Esser, H … - The FASEB Journal, 2004 - FASEB Page 1. The FASEB Journal express article 10.1096/fj.03-1476fje. Published online July 1, 2004.
A central role for inflammation in the pathogenesis of diabetic retinopathy Antonia M. Joussen,* ,†,
Vassiliki Poulaki, ‡,§ Minh Ly Le,* Kan Koizumi,* Christina Esser,* ... Cited by 202 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org L Zheng, SJ Howell, DA Hatala, K Huang, TS Kern - Diabetes, 2007 - Am Diabetes Assoc It has been previously reported that aspirin inhibited the development of diabetic retinopathy
in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects
on diabetic retinopathy. To further explore this, we compared effects of oral consumption ... Cited by 42 - Related articles - BL Direct - All 12 versions
