- ►diabetesjournals.org R Belfort, L Mandarino, S Kashyap, K Wirfel, … - Diabetes, 2005 - Am Diabetes Assoc The dose-response relationship between elevated plasma free fatty acid (FFA)
levels and impaired insulin-mediated glucose disposal and insulin signaling was
examined in 21 lean, healthy, normal glucose-tolerant subjects. Following a ... Cited by 86 - Related articles - All 5 versions
- ►shouxi.net M Bajaj, S Suraamornkul, A Romanelli, GW … - Diabetes, 2005 - Am Diabetes Assoc To investigate the effect of a sustained (7-day) decrease in plasma free fatty
acid (FFA) concentrations on insulin action and intramyocellular long-chain
fatty acyl-CoAs (LCFA-CoAs), we studied the effect of acipimox, a potent ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►endojournals.org H Storgaard, CB Jensen, M Bjornholm, XM … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Insulin-stimulated glucose disposal decreased approximately 25% after short- and
long-term fat infusion in both IGT relatives and controls. Glucose oxidation
decreased and lipid oxidation increased after both short- and long-term fat ... Cited by 23 - Related articles - BL Direct - All 6 versions
- ►endojournals.org YT Kruszynska, DS Worrall, J Ofrecio, JP … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc The mechanisms by which elevated plasma nonesterified fatty acid (NEFA) levels
induce skeletal muscle insulin resistance remain unclear. A NEFA-induced defect
in the activation of PI3K, which plays a key role in insulin's stimulation ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►physiology.org SR Kashyap, R Belfort, R Berria, S … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Muscle insulin resistance develops when plasma free fatty acids (FFAs) are
acutely increased to supraphysiological levels ( 1,500–4,000 µmol/l).
However, plasma FFA levels >1,000 µmol/l are rarely observed in humans ... Cited by 27 - Related articles - All 3 versions
- ►physiology.org [PDF] SR Kashyap, R Belfort, R Berria, S … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Page 1. Discordant Effects of a Chronic Physiologic Increase in Plasma
Free Fatty Acids on Insulin Signaling in Healthy Subjects ... Cited by 2 - Related articles
- ►endojournals.org MJ Serlie, AJ Meijer, JE Groener, M Duran, E … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Context: Increased plasma free fatty acid (FFA) concentrations may be in part
responsible for the increased levels of ceramide in skeletal muscle of obese
subjects. ... Objective: We studied the effect of lowering and increasing ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►endojournals.org K Tsintzas, K Chokkalingam, K Jewell, L … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Results: Glucose disposal was approximately 50% lower at the end of the clamp in
the LIPID compared with the CON trial (37.8 ± 4.4 and 79.6 ± 4.0 µmol/kg lean
mass·min, respectively; P < 0.01). In the LIPID trial, muscle long-chain ... Cited by 6 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org JM Adams, T Pratipanawatr, R Berria, E … - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in
insulin resistance, but the precise nature of the lipid species that produce
insulin resistance in human muscle are unknown. Ceramides, either generated ... Cited by 117 - Related articles - BL Direct - All 9 versions
DJ Powell, S Turban, A Gray, E Hajduch, HS … - Biochemical Journal, 2004 - pubmedcentral.nih.gov Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of
skeletal muscle insulin resistance that may develop, in part, as a consequence
of a direct inhibitory effect on early insulin signalling events. Here we ... Cited by 58 - Related articles - BL Direct - All 6 versions
