- ►escholarship.org JJ Meier, JD Veldhuis, PC Butler - Diabetes, 2005 - Am Diabetes Assoc In health, insulin is secreted in discrete pulses into the portal vein, and the
regulation of the rate of insulin secretion is accomplished by modulation of
insulin pulse mass. Several lines of evidence suggest that the pattern of ... Cited by 35 - Related articles - All 8 versions
- ►endojournals.org SH Song, SS McIntyre, H Shah, JD Veldhuis, … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc Insulin is secreted in a high frequency pulsatile manner. These pulses are
delivered directly into the portal vein and then undergo extraction and dilution
before delivery into the systemic circulation. The reported frequency of ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►physiology.org JM Grubert, M Lautz, DB Lacy, MC Moore, B … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc The pancreas releases insulin in a pulsatile manner; however, studies assessing
the liver's response to insulin have used constant infusion rates. Our aims were
to determine whether the secretion pattern of insulin [continuous (CON) vs. ... Cited by 8 - Related articles - BL Direct - All 4 versions
N Porksen, SR Munn, JL Steers, JD Veldhuis, … - American Journal of Physiology- Endocrinology And …, 1996 - Am Physiological Soc Porksen, Niels, Stephen R. Munn, Jeffery L. Steers, Johannes D. Veldhuis, and
Peter C. Butler. Effects of somatostatin on pulsatile insulin secretion:
selective inhibi- tion of insulin burst mass. Am. J. PhysioZ. 270 ... Cited by 33 - Related articles - BL Direct - All 4 versions
N Porksen, S Munn, J Steers, JD Veldhuis, PC … - Diabetes, 1996 - Am Diabetes Assoc In the present studies, we used a recently validated canine model to determine
1) if glucose ingestion stimulates insulin secretion by amplifying the pulsatile
component of insulin release, and if so, 2) whether this effect is achieved ... Cited by 43 - Related articles - BL Direct - All 5 versions
C Juhl, T Grøfte, PC Butler, JD Veldhuis, O … - Diabetes, 2002 - Am Diabetes Assoc Insulin is released as secretory bursts superimposed on basal release. The
overall contribution of secretory bursts was recently quantified as at least
75%, and the main regulation of insulin secretion is through perturbation ... Cited by 5 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org LL Kjems, BM Kirby, EM Welsh, JD Veldhuis, M … - Diabetes, 2001 - Am Diabetes Assoc Most insulin is secreted in discrete pulses at an interval of ∼6 min.
Increased insulin secretion after meal ingestion is achieved through the
mechanism of amplification of the burst mass. Conversely, in type 2 ... Cited by 74 - Related articles - BL Direct - All 6 versions
CJ Goodner, DJ Koerker, DS Weigle, DK … - Diabetes, 1989 - Am Diabetes Assoc The effect of beta-cell deficiency on the spontaneous pulsatile secretory
pattern of the islets of Langerhans was studied in the baboon. Measures of
beta-cell function were correlated with the secretory pattern before and at ... Cited by 27 - Related articles - All 4 versions
