- ►diabetesjournals.org P Rao, J Roccisana, KK Takane, R Bottino, A … - Diabetes, 2005 - Am Diabetes Assoc Akt is an important intracellular mediator of β-cell growth and survival in
rodents. However, whether constitutive activation of Akt in human β-cells
enhances the survival and function of transplanted islets is unknown. In ... Cited by 19 - Related articles - All 6 versions
RC Vasavada, L Wang, Y Fujinaka, KK Takane, … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE— Diabetes results from a deficiency of functional β-cells. Previous
studies have identified hepatocyte growth factor (HGF) and parathyroid
hormone–related protein (PTHrP) as two potent β-cell mitogens. The ... Cited by 7 - Related articles - BL Direct - All 3 versions
Y Sawada, B Zhang, F Okajima, T Izumi, T … - Molecular and Cellular Endocrinology, 2001 - Elsevier Parathyroid hormone-related protein (PTHrP) is reportedly produced in normal
islets and insulinomas. PTHrP induces differentiation in some cell-types and
growth in others. We examined whether PTHrP production is greater in well- ... Cited by 8 - Related articles - All 3 versions
- ►diabetesjournals.org I Cozar-Castellano, KK Takane, R Bottino, … - Diabetes, 2004 - Am Diabetes Assoc The major regulator of the gap-1/synthesis phase (G 1 /S) cell cycle checkpoint
is the retinoblastoma protein (pRb), and this is regulated in part by the
activities of cyclin-dependent kinase (cdk)-4 and the D cyclins. ... Cited by 57 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org R Takahashi, H Ishihara, K Takahashi, A … - Journal of molecular endocrinology, 2007 - Soc Endocrinology Gene transfer with adenovirus vectors has been used extensively for pancreatic
islet research. However, infection efficiency varies among reports. We
reevaluated the infection efficiency, defined here as the percentage of ... Cited by 2 - Related articles - All 4 versions
- ►endocrinology-journals.org [PDF] S Gahr, M Merger, LC Bollheimer, CG … - Journal of molecular endocrinology, 2002 - Soc Endocrinology We investigated the role of hepatocyte growth factor (HGF) in β-cell growth and
its complex intracellular signal transduction pathways. Cell proliferation was
measured in the β-cell line INS-1 using [3H]thymidine incorporation. ... Cited by 35 - Related articles - BL Direct - All 8 versions
- ►jbc.org A Garcia-Ocana, KK Takane, VT Reddy, JC … - Journal of Biological Chemistry, 2003 - ASBMB Hepatocyte growth factor (HGF) increases beta cell proliferation and function in
rat insulin promoter (RIP)-targeted transgenic mice. RIP-HGF mouse islets also
function superiorly to normal islets in a transplant setting. Here, we ... Cited by 56 - Related articles - BL Direct - All 5 versions
[CITATION] Oriente F, Paturzo F, Andreozzi F, Zabatta A, Troncone G, Bosch F, Pujol A, Chneiweiss H, …
