- ►shouxi.net HKR Karlsson, JR Zierath, S Kane, A Krook, … - Diabetes, 2005 - Am Diabetes Assoc AS160 is a newly described substrate for the protein kinase Akt that links
insulin signaling and GLUT4 trafficking. In this study, we determined the
expression of and in vivo insulin action on AS160 in human skeletal muscle. ... Cited by 78 - Related articles - All 5 versions
- ►molbiolcell.org A Zeigerer, MK McBrayer, TE McGraw - Molecular biology of the cell, 2004 - Am Soc Cell Biol Insulin maintains whole body blood glucose homeostasis, in part, by regulating
the amount of the GLUT4 glucose transporter on the cell surface of fat and
muscle cells. Insulin induces the redistribution of GLUT4 from ... Cited by 127 - Related articles - BL Direct - All 8 versions
- ►shouxi.net MD Bruss, EB Arias, GE Lienhard, GD Cartee - Diabetes, 2005 - Am Diabetes Assoc In 3T3-L1 adipocytes, insulin-stimulated GLUT4 translocation requires
phosphorylation of the protein designated Akt substrate of 160 kDa (AS160). Both
insulin and contractions activate Akt in skeletal muscle. Therefore, we ... Cited by 102 - Related articles - All 8 versions
- ►shouxi.net A Deshmukh, VG Coffey, Z Zhong, AV Chibalin … - Diabetes, 2006 - Am Diabetes Assoc Skeletal muscle contraction stimulates multiple signaling cascades that govern a
variety of metabolic and transcriptional events. Akt/protein kinase B regulates
metabolism and growth/muscle hypertrophy, but contraction effects on this ... Cited by 44 - Related articles - BL Direct - All 5 versions
H Sano, S Kane, E Sano, CP Miinea, JM … - Journal of Biological Chemistry, 2003 - ASBMB Insulin stimulates the rapid translocation of intracellular glucose transporters
of the GLUT4 isotype to the plasma membrane in fat and muscle cells. The
connections between known insulin signaling pathways and the protein ... Cited by 251 - Related articles - BL Direct - All 4 versions
CP Mîinea, H Sano, S Kane, E Sano, M … - Biochemical Journal, 2005 - pubmedcentral.nih.gov Recently, we described a 160 kDa protein (designated AS160, for Akt substrate of
160 kDa) with a predicted Rab GAP (GTPase-activating protein) domain that is
phosphorylated on multiple sites by the protein kinase Akt. Phosphorylation ... Cited by 88 - Related articles - BL Direct - All 7 versions
- ►shouxi.net M Larance, G Ramm, J Stöckli, EM van Dam, … - Journal of Biological Chemistry, 2005 - ASBMB Insulin stimulates the translocation of the glucose transporter GLUT4 from
intracellular vesicles to the plasma membrane. In the present study we have
conducted a comprehensive proteomic analysis of affinity-purified GLUT4 ... Cited by 110 - Related articles - BL Direct - All 6 versions
- ►jbc.org S Kane, H Sano, SCH Liu, JM Asara, WS Lane … - Journal of Biological Chemistry, 2002 - ASBMB This study describes a method for the identification of the substrates of
specific serine kinases. An antibody specific for the phosphomotif generated by
the kinase is used to isolate phosphorylated substrates by ... Cited by 207 - Related articles - BL Direct - All 5 versions
- ►shouxi.net JT Treebak, S Glund, A Deshmukh, DK Klein, … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is a heterotrimeric protein that regulates
glucose transport mediated by cellular stress or pharmacological agonists such
as 5-aminoimidazole-4-carboxamide 1 β-d-ribonucleoside (AICAR). AS160, a ... Cited by 82 - Related articles - BL Direct - All 7 versions
- ►shouxi.net G Ramm, M Larance, M Guilhaus, DE James - Journal of Biological Chemistry, 2006 - ASBMB Translocation of the insulin-regulated glucose transporter GLUT4 to the cell
surface is dependent on the phosphatidylinositol 3-kinase/Akt pathway. The
RabGAP (Rab GTPase-activating protein) AS160 (Akt substrate of 160 kDa) is ... Cited by 42 - Related articles - All 6 versions
