- ►diabetesjournals.org HJ Pan, P Reifsnyder, DE Vance, Q Xiao, EH … - Diabetes, 2005 - Am Diabetes Assoc Although thiazolidinediones suppress hyperglycemia in diabetic (NON × NZO)F1
males, these mice exhibit unusual sensitivity to drug-induced exacerbation of an
underlying hepatosteatosis only rarely experienced in human patients. To ... Cited by 13 - Related articles - All 7 versions
- ►endojournals.org EH Leiter, PC Reifsnyder, W Zhang, H Pan, Q … - Endocrinology, 2006 - Endocrine Soc Polygenic mouse models for obesity-induced type 2 diabetes (T2D) more accurately
reflect the most common manifestations of the human disease. Two inbred mouse
strains (NON/Lt and NZO/HlLt) separately contributed T2D susceptibility- ... Cited by 14 - Related articles - BL Direct - All 5 versions
RA Koza, K Flurkey, DM Graunke, C Braun, HJ … - Metabolism, 2004 - Elsevier New Zealand Obese (NZO) male mice develop a polygenic juvenile-onset obesity and
maturity-onset hyperinsulinemia and hyperglycemia (diabesity). Here we report on
metabolic and molecular changes associated with the antidiabesity action of ... Cited by 14 - Related articles - All 12 versions
HJ Pan, Y Lin, YE Chen, DE Vance, EH Leiter - Vascular pharmacology, 2006 - Elsevier Given the heterogeneous nature of metabolic dysfunctions associated with insulin
resistance and type 2 diabetes (T2D), a single pharmaceutical cannot be expected
to provide complication-free therapy in all patients. Thiazolidinediones ... Cited by 14 - Related articles - All 4 versions
O Šeda, L Šedová - Pharmacogenomics, 2007 - Future Medicine The three isotypes of peroxisome proliferator-activated receptors (PPARs) are
currently perceived as major regulatory nodes (or hubs) of metabolic pathway
networks, linking most prevalent diseases including Type 2 diabetes, ... Cited by 2 - Related articles - BL Direct - All 4 versions
[CITATION] NONcNZO10 mice develop obesity, insulin resistance, and hyperglycemia resembling human …
BC Fam, S Andrikopoulos - Animal models of diabetes: frontiers in research, 2007 - books.google.com 6 The New Zealand Obese Mouse: Polygenic Model of Obesity, Glucose Intolerance,
and the Metabolic Syndrome Barbara C. Fam and Sofianos Andrikopoulos CONTENTS
Background 140 Obesity and Metabolic Characteristics of the NZO Mouse 141 ... Cited by 3 - Related articles
- ►diabetesjournals.org PC Reifsnyder, EH Leiter - Diabetes, 2002 - Am Diabetes Assoc Obesity-driven type 2 diabetes (diabesity) involves complex genetic and
environmental interactions to trigger disease. Here, we combine variable numbers
of known quantitative trait loci (QTL) for obesity and diabetes contributed ... Cited by 41 - Related articles - BL Direct - All 6 versions
- ►physiology.org L Sedova, O Seda, L Kazdova, B Chylikova, P … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc The importance of early environment, including maternal diet during pregnancy,
is suspected to play a major role in pathogenesis of metabolic syndrome and
related conditions. One of the proposed mechanisms is a mismatch between ... Cited by 5 - Related articles - BL Direct - All 5 versions
V Kren, D Krenova, V Bila, M Zdobinska, V … - Folia biologica, 1996 - ncbi.nlm.nih.gov The spontaneously hypertensive rat (SHR) is the most widely used animal model of
human essential hypertension. In the SHR strain, as in humans, the high blood
pressure is determined multifactorially. Analysis of genetically ... Cited by 5 - Related articles - BL Direct - All 2 versions
