JC Florez, CM Agapakis, NP Burtt, M Sun, P Almgren, L … - Diabetes, 2005 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin
signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling
molecules. Due to its chromosomal location under a chromosome 20 linkage peak and ... Cited by 25 - Related articles - All 8 versions
ND Palmer, JL Bento, JC Mychaleckyj, CD … - DIABETES-NEW …, 2004 - Am Diabetes Assoc Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, catalyzes the dephosphorylation
of pro- teins at tyrosyl residues. PTP-1B has been implicated in negatively regulating insulin
signaling by dephosphory- lating the phosphotyrosine residues of the insulin re- ceptor. ... Cited by 45 - Related articles - BL Direct - All 6 versions
NJ Spencer-Jones, X Wang, H Snieder, TD Spector, … - Diabetes, 2005 - Am Diabetes Assoc Protein tyrosine phosphatase-1B negatively regulates leptin and insulin signaling, potentially
contributing to hormonal resistance. We selected six tagging single nucleotide polymorphisms
(SNPs) representing 18 common variants in the protein tyrosine phosphatase-1B gene ( ... Cited by 18 - Related articles - BL Direct - All 4 versions
JL Bento, ND Palmer, JC Mychaleckyj, LA Lange, CD … - Diabetes, 2004 - Am Diabetes Assoc The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48), which negatively
regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin
receptor kinase activation segment. PTPN1 is located in 20q13, a genomic region linked ... Cited by 69 - Related articles - BL Direct - All 6 versions
I Dahlman, H Wahrenberg, L Persson, P Arner - Journal of internal medicine, 2004 - cat.inist.fr No association of reported functional protein tyrosine phosphatase 1 B 3' UTR gene
polymorphism with features of the metabolic syndrome in a Swedish population. I
DAHLMAN, H WAHRENBERG, L PERSSON, P ARNER Journal ... Cited by 10 - Related articles - BL Direct - All 3 versions
M Traurig, RL Hanson, S Kobes, C Bogardus, LJ Baier - Diabetologia, 2007 - Springer Abstract Aim/hypothesis Single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase
1B gene (PTPN1) have been reported to be associated with type 2 diabetes in white
subjects, and insulin sensitivity and fasting glucose levels in Hispanic Americans. In this ... Cited by 4 - Related articles - BL Direct - All 4 versions
O Ukkola, T Rankinen, T Lakka, AS Leon, JS … - Obesity research, 2005 - ncbi.nlm.nih.gov Protein tyrosine phosphatase 1B (PTPN1) affects the regulation of insulin signaling and energy
metabolism. We studied whether polymorphisms in the PTPN1 gene impact body fat distribution
in the HERITAGE Family Study cohort in 502 white and 276 black subjects. Insulin ... Cited by 9 - Related articles - All 3 versions
SM Echwald, H Bach, H Vestergaard, B Richelsen, K … - Diabetes, 2002 - Am Diabetes Assoc In the present study, we tested the hypothesis that variability in the protein tyrosine
phosphatase-1B (PTP-1B) gene is associated with type 2 diabetes. Using single-strand conformational
polymorphism analysis, we examined cDNA of PTP-1B from 56 insulin-resistant patients ... Cited by 71 - Related articles - BL Direct - All 4 versions
JC Florez, M Sjögren, N Burtt, M Orho-Melander, S … - Diabetes, 2004 - Am Diabetes Assoc The insulin receptor substrate (IRS)-1 is an important component of the insulin signal transduction
cascade. Several reports suggest that a Gly→Arg change in codon 972 is associated with type
2 diabetes and related traits, and a recent meta-analysis reported a modest but nominally ... Cited by 49 - Related articles - BL Direct - All 4 versions
