LM Sparks, H Xie, RA Koza, R Mynatt, MW … - Diabetes, 2005 - Am Diabetes Assoc Obesity and type 2 diabetes have been associated with a high-fat diet (HFD) and
reduced mitochondrial mass and function. We hypothesized a HFD may affect
expression of genes involved in mitochondrial function and biogenesis. To ... Cited by 155 - Related articles - All 5 versions
DK Richardson, S Kashyap, M Bajaj, K Cusi, … - Journal of Biological Chemistry, 2005 - ASBMB Page 1. Lipid Infusion Decreases the Expression of Nuclear Encoded
Mitochondrial Genes and Increases Expression of Extracellular ... Cited by 82 - Related articles - All 9 versions
- ►nih.gov K Morino, KF Petersen, S Dufour, D Befroy, J … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig To further explore the nature of the mitochondrial dysfunction and insulin
resistance that occur in the muscle of young, lean, normoglycemic,
insulin-resistant offspring of parents with type 2 diabetes (IR offspring), ... Cited by 165 - Related articles - BL Direct - All 10 versions
- ►jbc.org TR Koves, P Li, J An, T Akimoto, D Slentz, … - Journal of Biological Chemistry, 2005 - ASBMB Peroxisome proliferator-activated receptor- co-activator 1 (PGC1 ) is a
promiscuous co-activator that plays a key role in regulating mitochondrial
biogenesis and fuel homeostasis. Emergent evidence links decreased skeletal ... Cited by 104 - Related articles - BL Direct - All 4 versions
- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, R … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and
pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable
abnormality is insulin resistance in skeletal muscle. Impaired ... Cited by 667 - Related articles - BL Direct - All 15 versions
DE Kelley, J He, EV Menshikova, VB Ritov - Diabetes, 2002 - Am Diabetes Assoc Skeletal muscle is strongly dependent on oxidative phosphorylation for energy
production. Because the insulin resistance of skeletal muscle in type 2 diabetes
and obesity entails dysregulation of the oxidation of both carbohydrate and ... Cited by 533 - Related articles - BL Direct - All 4 versions
N Turner, CR Bruce, SM Beale, KL Hoehn, T … - Diabetes, 2007 - Am Diabetes Assoc A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has
been proposed as a major factor leading to the accumulation of intramuscular
lipids and their subsequent deleterious effects on insulin action. Here, we ... Cited by 63 - Related articles - BL Direct - All 5 versions
KF Petersen, S Dufour, GI Shulman - PLoS Medicine, 2005 - medicine.plosjournals.org Rates of insulin-stimulated muscle mitochondrial ATP synthase flux and
insulin-stimulated increases in concentrations of intramyocellular inorganic
phosphate (P i ) were assessed by 31 P magnetic resonance spectroscopy ... Cited by 101 - Related articles - Cached - BL Direct - All 12 versions
C Bonnard, A Durand, S Peyrol, E Chanseaume … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Mitochondrial dysfunction in skeletal muscle has been implicated in the
development of type 2 diabetes. However, whether these changes are a cause or a
consequence of insulin resistance is not clear. We investigated the ... Cited by 53 - Related articles - BL Direct - All 8 versions
- ►shouxi.net KF Petersen, S Dufour, D Befroy, R Garcia, … - The New England journal of medicine, 2004 - nejm.highwire.org Methods We performed hyperinsulinemic–euglycemic clamp studies in combination
with infusions of [6,6- 2 H 2 ]glucose in healthy, young, lean,
insulin-resistant offspring of patients with type 2 diabetes and insulin- ... Cited by 786 - Related articles - BL Direct - All 14 versions
