- ►diabetesjournals.org VA Payne, C Arden, C Wu, AJ Lange, L Agius - Diabetes, 2005 - Am Diabetes Assoc Hepatic glucokinase is regulated by a 68-kDa regulatory protein (GKRP) that is
both an inhibitor and nuclear receptor for glucokinase. We tested the role of
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK2) in regulating ... Cited by 29 - Related articles - All 5 versions
- ►endojournals.org S Baltrusch, S Langer, L Massa, M Tiedge, S … - Endocrinology, 2006 - Endocrine Soc The glucose sensor enzyme glucokinase plays a pivotal role in the regulation of
glucose-induced insulin secretion in pancreatic ß-cells. Activation of
glucokinase represents a promising concept for the treatment of type 2 ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org L Massa, S Baltrusch, DA Okar, AJ Lange, S … - Diabetes, 2004 - Am Diabetes Assoc The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
(PFK-2/FBPase-2) was recently identified as a new intracellular binding partner
for glucokinase (GK). Therefore, we studied the importance of this ... Cited by 33 - Related articles - BL Direct - All 6 versions
M Mukhtar, M Stubbs, L Agius - FEBS letters, 1999 - Elsevier Glucokinase is rapidly exported from the nucleus of hepatocytes in response to a
rise in glucose or fructose 1-P. We demonstrate using confocal microscopy and
quantitative imaging that in contrast to previous findings, the regulatory ... Cited by 29 - Related articles - All 7 versions
N de la Iglesia, M Mukhtar, J Seoane, JJ … - Journal of Biological Chemistry, 2000 - ASBMB Glucokinase has a very high flux control coefficient (greater than unity) on
glycogen synthesis from glucose in hepatocytes (Agius et al., J. Biol. Chem.271,
30479–30486, 1996). Hepatic glucokinase is inhibited by a 68-kDa ... Cited by 47 - Related articles - BL Direct - All 3 versions
MJ Munoz-Alonso, G Guillemain, N Kassis, J … - Journal of Biological Chemistry, 2000 - ASBMB A novel protein was cloned from a rat liver cDNA library by interaction with the
liver glucokinase. This protein contained 339 residues and possessed a canonical
consensus sequence for a dual specificity phosphatase. The recombinant ... Cited by 36 - Related articles - BL Direct - All 3 versions
- ►jbc.org S Baltrusch, S Lenzen, DA Okar, AJ Lange, M … - Journal of Biological Chemistry, 2001 - ASBMB The low affinity glucose-phosphorylating enzyme glucokinase shows the phenomenon
of intracellular translocation in beta cells of the pancreas and the liver. To
identify potential binding partners of glucokinase by a systematic ... Cited by 46 - Related articles - BL Direct - All 4 versions
- ►ox.ac.uk [PDF] KJ Brocklehurst, VA Payne, RA Davies, D … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) has a major role in the control of blood glucose homeostasis
and is a strong potential target for the pharmacological treatment of type 2
diabetes. We report here the mechanism of action of two novel and potent ... Cited by 75 - Related articles - BL Direct - All 6 versions
A Shiraishi, Y Yamada, Y Tsuura, S Fijimoto, … - Journal of Biological Chemistry, 2001 - ASBMB A glucokinase regulatory protein has been reported to exist in the liver, which
suppresses enzyme activity in a complex with fructose 6-phosphate, whereas no
corresponding protein has been found in pancreatic cells. To search for ... Cited by 23 - Related articles - BL Direct - All 3 versions
C Arden, A Harbottle, S Baltrusch, M Tiedge, … - Diabetes, 2004 - Am Diabetes Assoc The association of glucokinase with insulin secretory granules has been shown by
cell microscopy techniques. We used MIN6 insulin-secretory cells and organelle
fractionation to determine the effects of glucose on the subcellular ... Cited by 27 - Related articles - BL Direct - All 4 versions
