- ►shouxi.net K Fukui, T Wada, S Kagawa, K Nagira, M … - Diabetes, 2005 - Am Diabetes Assoc We investigated the role of hepatic SH2-containing inositol 5′-phosphatase 2
(SHIP2) in glucose metabolism in mice. Adenoviral vectors encoding wild-type
SHIP2 (WT-SHIP2) and a dominant-negative SHIP2 (ΔIP-SHIP2) were injected ... Cited by 24 - Related articles - All 5 versions
- ►endojournals.org S Kagawa, T Sasaoka, S Yaguchi, H Ishihara, … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc TYPE 2 (NONINSULIN DEPENDENT) diabetes mellitus is a disorder characterized by
insulin resistance in the target tissue of insulin with insufficient insulin
secretion in pancreatic ß-cells (1). The molecular mechanisms underlying ... Cited by 10 - Related articles - All 4 versions
T Sasaoka, H Hori, T Wada, M Ishiki, T Haruta … - Diabetologia, 2001 - Springer Activation of the PI3-kinase is known to be extreme- ly important for exerting
various metabolic actions of insulin [1ą3].PI(3,4,5)P3 produced by the
activated PI3-kinase is thought to function as a key lipid second messenger ... Cited by 52 - Related articles - BL Direct - All 5 versions
MW Sleeman, KE Wortley, KMV Lai, LC Gowen, … - Nature medicine, 2005 - nature.com Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol
5-phosphatase 2), was previously reported to induce severe insulin sensitivity,
leading to early postnatal death. In the previous study, the targeting ... Cited by 72 - Related articles - All 6 versions
- ►diabetesjournals.org E Marion, PJ Kaisaki, V Pouillon, C Gueydan, … - Diabetes, 2002 - Am Diabetes Assoc Genetic susceptibility to type 2 diabetes involves many genes, most of which are
still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of
insulin signaling and sensitivity in vivo and is thus a good candidate ... Cited by 57 - Related articles - BL Direct - All 6 versions
T Sasaoka, T Wada, K Fukui, S Murakami, H … - Journal of Biological Chemistry, 2004 - ASBMB SH2-containing inositol phosphatase 2 (SHIP2) is a physiologically important
negative regulator of insulin signaling by hydrolyzing the phosphatidylinositol
(PI) 3-kinase product PI 3,4,5-trisphosphate in the target tissues of ... Cited by 41 - Related articles - BL Direct - All 4 versions
T Sasaoka, K Fukui, T Wada, S Murakami, J … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 336–344 DOI 10.1007/s00125-004-1636-8 ARTICLE T.
Sasaoka . K. Fukui . T. Wada . S. Murakami . J. Kawahara . H. Ishihara . ... Cited by 8 - Related articles - All 2 versions
T Sasaoka, T Wada, H Tsuneki - Pharmacology and Therapeutics, 2006 - Elsevier Phosphatidyl inositol 3-kinase (PI3-kinase) functions as a lipid kinase to
produce PI(3,4,5)P 3 from PI(4,5)P 2 in vivo. PI(3,4,5)P 3 is crucial as a lipid
second messenger in various metabolic effects of insulin. Lipid ... Cited by 31 - Related articles - All 4 versions
- ►diabetesjournals.org PJ Kaisaki, M Delépine, PY Woon, L Sebag- … - Diabetes, 2004 - Am Diabetes Assoc Type II SH2 domain–containing inositol 5-phosphatase (INPPL1, or SHIP2) plays
an important role in the control of insulin sensitivity. INPPL1 mutations
affecting gene function have been found in rat models of type 2 diabetes ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►endojournals.org S Kagawa, Y Soeda, H Ishihara, T Oya, M … - Endocrinology, 2008 - Endocrine Soc SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a 5'-lipid phosphatase
hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P 3 to
PI(3,4)P 2 in the regulation of insulin signaling, and is shown to be ... Cited by 4 - Related articles - BL Direct - All 3 versions
