ED Javor, EK Cochran, C Musso, JR Young, AM … - Diabetes, 2005 - Am Diabetes Assoc Ectopic fat accumulation has been implicated as a contributing factor in the abnormal metabolic
state of obesity. One human model of ectopic fat deposition is generalized lipodystrophy. Generalized
lipodystrophy is a rare disorder characterized by a profound deficiency of adipose tissue ... Cited by 70 - Related articles - All 5 versions
C Musso, E Cochran, E Javor, J Young, AM DePaoli, P … - Metabolism, 2005 - Elsevier In the female group, serum free testosterone decreased from 39.6 ± 11 to 18.9 ± 4.5 ng/dL (P
< 0.01) and serum sex hormone binding globulin increased from 14 ± 2.5 to 25 ± 4.8 nmol/L
(P < 0.02). Luteinizing hormone (LH) responses to LH releasing hormone were more ... Cited by 38 - Related articles - All 10 versions
ED Javor, MG Ghany, EK Cochran, EA Oral, AM … - Hepatology, 2005 - assets0.pubget.com Severe lipodystrophy is characterized by diminished adipose tissue and hypoleptinemia, leading
to ectopic triglyceride accumulation. In the liver, this is associated with steatosis, potentially leading
to nonalcoholic steatohepatitis (NASH). We investigated the preva- lence of NASH and ... Cited by 69 - Related articles - View as HTML - All 4 versions
SA Moran, N Patten, JR Young, E Cochran, N Sebring, … - Metabolism, 2004 - Elsevier Leptin, an adipocyte hormone, when replaced in patients with lipodystrophy, improves insulin
resistance, hyperglycemia, dyslipidemia, and hepatic steatosis. Changes in body composition
accompany this metabolic improvement. We studied 14 patients (3 men and 11 women); ... Cited by 30 - Related articles - All 9 versions
- ►endojournals.org K Ebihara, T Kusakabe, M Hirata, H Masuzaki, F … - Journal of Clinical …, 2007 - Endocrine Soc Results: The leptin-replacement therapy with the twice-daily injection dramatically improved
fasting glucose (mean ± SE, 172 ± 20 to 120 ± 12 mg/dl, P < 0.05) and triglyceride levels (mean
± SE, 700 ± 272 to 260 ± 98 mg/dl, P < 0.05) within 1 wk. The leptin-replacement therapy ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►endojournals.org EA Oral, E Ruiz, A Andewelt, N Sebring, AJ … - Journal of Clinical …, 2002 - Endocrine Soc Leptin is important in regulating energy homeostasis. Severe lipodystrophy is associated with
leptin deficiency and insulin resistance, hypertriglyceridemia, and hepatic steatosis. Leptin deficiency
is also associated with abnormalities of the pituitary hormones in rodent models and ... Cited by 65 - Related articles - BL Direct - All 5 versions
- ►endojournals.org JH Lee, JL Chan, E Sourlas, V Raptopoulos, CS … - Journal of Clinical …, 2006 - Endocrine Soc Context: Highly active antiretroviral therapy (HAART) for HIV-1 infection has been associated
with a metabolic syndrome characterized by insulin resistance, hyperlipidemia, and redistribution
of body fat (lipodystrophy). A subset of patients with predominant lipoatrophy has low ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►endojournals.org E Cochran, JR Young, N Sebring, A DePaoli, … - Journal of Clinical …, 2004 - Endocrine Soc Recombinant methionyl human leptin (r-metHuLeptin) therapy has shown clear efficacy in the
treatment of severe insulin resistance associated with lipodystrophy syndromes and low leptin
levels. We treated two siblings with Rabson-Mendenhall syndrome (severe insulin ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►endojournals.org JR McDuffie, PA Riggs, KA Calis, RJ Freedman, … - Journal of Clinical …, 2004 - Endocrine Soc To examine leptin's role in human appetite regulation, we studied recombinant methionyl human
leptin's effects on satiation and satiety in a model of leptin insufficiency, lipodystrophy. Eight females
with hypoleptinemia and lipodystrophy were given sc injections of A-100 (maximal dose, ... Cited by 27 - Related articles - BL Direct - All 5 versions
P Gorden, JY Park - Archives of physiology and biochemistry, 2006 - informahealthcare.com Leptin was discovered in the search for obesity genes. The mouse model was explored, and
the result was the discovery of the gene mutation for the protein product in the ob/ob mouse
(Zhang et al.., 1994). The name given to this heretofore product is leptin. There were also ... Cited by 3 - Related articles - BL Direct - All 6 versions
