- ►shouxi.net Y Hassainya, F Garcia-Pons, R Kratzer, V … - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is thought to result from the destruction of β-cells by
autoantigen-specific T-cells. Observations in the NOD mouse model suggest that
CD8 + cytotoxic T-cells play an essential role in both the initial ... Cited by 43 - Related articles - All 6 versions
- ►nih.gov A Toma, S Haddouk, JP Briand, L Camoin, H … - Proceedings of the National Academy of Sciences of …, 2005 - National Acad Sciences Proinsulin is a key autoantigen in type 1 diabetes. Evidence in the mouse has
underscored the importance of the insulin B chain region in autoimmunity to
pancreatic beta cells. In man, a majority of proteasome cleavage sites are ... Cited by 56 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org Q Ouyang, NE Standifer, H Qin, P Gottlieb, … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes results from the autoimmune destruction of insulin-producing
pancreatic β-cells by cytotoxic T-lymphocytes (CTLs). In humans, few β-cell
epitopes have been reported, thereby limiting the study of ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell
destruction in type 1 diabetes. However, few islet-associated peptides have been
demonstrated to activate autoreactive CTLs from type 1 diabetic subjects. ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►pnas.org GGM Pinkse, OHM Tysma, CAM Bergen, MGD … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an
important target of the autoimmune response associated with β cell destruction.
The mechanism of destruction is still unknown. Here, we provide evidence ... Cited by 87 - Related articles - BL Direct - All 10 versions
- ►jimmunol.org T Takaki, MP Marron, CE Mathews, ST … - The Journal of Immunology, 2006 - Am Assoc Immnol In both humans and NOD mice, particular MHC genes are primary contributors to
development of the autoreactive CD4 + and CD8 + T cell responses against
pancreatic cells that cause type 1 diabetes (T1D). Association studies have ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Mallone, E Martinuzzi, P Blancou, G Novelli … - Diabetes, 2007 - Am Diabetes Assoc Despite the understanding that type 1 diabetes pathogenesis is mediated by
T-cells, detection of these rare lymphocytes remains largely elusive. Suitable
T-cell assays are highly needed, since they could offer preclinical ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org C Panagiotopoulos, H Qin, R Tan, CB … - Diabetes, 2003 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease in which pancreatic β-cells are
destroyed by cytotoxic T-cells that recognize peptide epitopes presented by HLA
class I molecules. The identification of human β-cell epitopes may ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org P Blancou, R Mallone, E Martinuzzi, S Severe … - The Journal of Immunology, 2007 - Am Assoc Immnol Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic
cells. CD8 + T cells have recently been assigned a major role in cell injury.
Consequently, the identification of autoreactive CD8 + T cells in humans ... Cited by 10 - Related articles - All 6 versions
P Van Endert, Y Hassainya, V Lindo, J Bach, … - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2006 - interscience.wiley.com Abstract: Type 1 diabetes mellitus (T1DM) results from the destruction of β
cells by autoantigen-specific T cells. In the non-obese diabetic (NOD) mouse
model, CD8 + T cells play an essential role in both the initial triggering ... Cited by 8 - Related articles - BL Direct - All 5 versions
