KN Samli, MJ McGuire, CB Newgard, SA Johnston, KC … - Diabetes, 2005 - Am Diabetes Assoc Strategies for restoring β-cell function in diabetic patients would be greatly aided by the ability
to target genes, proteins, or small molecules specifically to these cells. Furthermore, the ability
to direct imaging agents specifically to β-cells would facilitate diagnosis and monitoring of ... Cited by 13 - Related articles - All 9 versions
S Schneider, PJ Feilen, M Schreckenberger, … - … clinical endocrinology & …, 2005 - ncbi.nlm.nih.gov Pancreatic islet cell mass (PICM) is a major determinant of the insulin secretory capacity in
humans. Currently, the only method for accurate assessment of the PICM is an autopsy
study. Thus, development of a technique allowing the non-invasive quantification of PICM ... Cited by 12 - Related articles - BL Direct - All 4 versions
B Waengler, C Beck, CY Shiue, S Schneider, C … - Bioorganic & medicinal …, 2004 - Elsevier The 11 C-labeled sulfonylurea receptor 1 (SUR1) ligand (S)-2-([ 11 C]methoxy)-4-[3-methyl-1
-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid ([ 11 C]methoxy-repaglinide) was synthesized
in an overall radiochemical yield of 35% after 55 min with a radiochemical purity higher ... Cited by 7 - Related articles - All 6 versions
CS Hampe, AR Wallen, M Schlosser, M Ziegler, IR … - Experimental and clinical …, 2005 - cat.inist.fr Antibodies, due to their high specificities and retention, represent potential beta cell imaging
agents, however their slow clearance from the blood may preclude their use. Antibody
fragments(Fabs) have much higher clearance and if they can be made with similar ... Cited by 8 - Related articles - BL Direct - All 4 versions
T Koblas, P Girman, Z Berkova, D Jirak, J Kriz, E … - Transplantation …, 2005 - Elsevier Superparamagnetic agents can be reliably used for magnetic resonance imaging (MRI) of pancreatic
islets located in the liver sinusoids. However, the main disadvantages seemed to be the rather
long culture time necessary for islet labeling and the low specificity of these agents. In the ... Cited by 14 - Related articles - All 5 versions
WJ Malaisse, M Doherty, MM Kadiata, L … - Cell Biochemistry …, 2001 - interscience.wiley.com D-Mannoheptulose was recently postulated to be transported into cells by GLUT2. The validity
of such an hypothesis was assessed by comparing the uptake of tritiated D-mannoheptulose
by pancreatic islets versus pieces of pancreas and, in the latter case, by comparing ... Cited by 7 - Related articles - BL Direct - All 2 versions
IR Sweet, DL Cook, Å lernmark, CJ … - Diabetes Technology …, 2004 - liebertonline.com IAN R. SWEET, Ph.D.,1 DANIEL L. COOK, MD, Ph.D.,2 ÅKE LERNMARK, Ph.D.,1 CARLA J.
GREENBAUM, MD,3 and KENNETH A. KROHN, Ph.D.4 ... Background: Currently there are major
efforts to develop strategies for the in vivo imaging of pancreatic beta cell mass as a ... Cited by 14 - Related articles - BL Direct - All 3 versions
JL Gaglia - Current Diabetes Reports, 2007 - Springer Introduction Pancreatic islet transplantation has great potential as a therapy for diabetes, with
less morbidity and mor- tality than whole-organ pancreas transplantation. Unfortunately, neither
the engraftment rate nor the long-term survival of transplanted islets can be easily ... Cited by 1 - Related articles - BL Direct - All 2 versions
- ►endojournals.org A Maffei, Z Liu, P Witkowski, F Moschella, GD Pozzo, E … - Endocrinology, 2004 - Endocrine Soc The purpose of our study was to identify transcripts specific for tissue-restricted, membrane-associated
proteins in human islets that, in turn, might serve as markers of healthy or diseased islet cell
masses. Using oligonucleotide chips, we obtained gene expression profiles of human ... Cited by 23 - Related articles - BL Direct - All 5 versions
T Oyama, IT Rombel, KN Samli, X Zhou, KC Brown - Biosensors and …, 2006 - Elsevier A technical challenge in the development of biosensor devices for cancer detection and diagnosis
is the identification of ligands that recognize cancer cells with high affinity and specificity.
Furthermore, it is unlikely that one cell-binding ligand will provide sufficient biological ... Cited by 9 - Related articles - All 4 versions
