TB Mysore, TA Shinkel, J Collins, EJ Salvaris, N … - Diabetes, 2005 - Am Diabetes Assoc Primary nonfunction of transplanted islets results in part from their sensitivity to reactive oxygen
species (ROS) generated during the isolation and transplantation process. Our aim was to examine
whether coexpression of antioxidant enzymes to detoxify multiple ROS increased the ... Cited by 27 - Related articles - All 5 versions
A Plesner, P Liston, R Tan, RG Korneluk, CB Verchere - Diabetes, 2005 - Am Diabetes Assoc Allotransplantation of pancreatic islets represents a promising approach to treat type 1
diabetes. Destruction of β-cells in islet allografts involves multiple immune mechanisms that lead
to activation of caspases and apoptotic cell death. The X-linked inhibitor of apoptosis ... Cited by 15 - Related articles - BL Direct - All 6 versions
JA Emamaullee, RV Rajotte, P Liston, RG Korneluk, … - Diabetes, 2005 - Am Diabetes Assoc The Edmonton Protocol for treatment of type 1 diabetes requires islets from two or more donors
to achieve euglycemia in a single recipient, primarily because soon after portal infusion, the majority
of the transplanted cells undergo apoptosis due to hypoxia and hypoxia reperfusion ... Cited by 24 - Related articles - BL Direct - All 8 versions
C Moriscot, F Pattou, J Kerr-Conte, MJ Richard, P … - Diabetologia, 2000 - Springer It has been established from numerous studies that oxygen and nitrogen free radicals can contribute
to the islet beta-cell destruction in Type I (insulin-de- pendent) diabetes mellitus models
[1±2]. The delete- rious actions of activated mononuclear cells could be mediated by ... Cited by 39 - Related articles - BL Direct - All 2 versions
- ►asnjournals.org DA Thomas, C Stauffer, K Zhao, H Yang, VK … - Journal of the American …, 2007 - Am Soc Nephrol Apoptotic cell death is a defined pathway for islet cell demise, and mitochondrial dysfunction
contributes to islet cell apoptosis. The hypothesis that the novel peptide d-Arg-2',
6'-dimethyltyrosine-Lys-Phe-NH 2 (SS-31), previously shown to target inner mitochondrial ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org ST Grey, C Longo, T Shukri, VI Patel, E … - The Journal of …, 2003 - Am Assoc Immnol Transplantation of an excessive number of islets of Langerhans (two to four pancreata per
recipient) into patients with type I diabetes is required to restore euglycemia. Hypoxia, nutrient
deprivation, local inflammation, and the cell inflammatory response (up-regulation of NF- ... Cited by 44 - Related articles - BL Direct - All 4 versions
DA Lepore, TA Shinkel, N Fisicaro, TB Mysore … - …, 2004 - interscience.wiley.com Abstract: The survival of pancreatic islet β–cell xenografts and allografts may be affected by damaging
reactive oxygen and nitrogen species generated during hypoxia-reoxygenation.
Peroxynitrite, which is formed from superoxide and nitric oxide, appears to be an ... Cited by 11 - Related articles - BL Direct - All 3 versions
S Marzorati, B Antonioli, R Nano, P Maffi, … - American Journal of …, 2006 - interscience.wiley.com A portion of transplanted islets is lost during engraftment as a result of stressful events, involving
hypoxia and production of proinflammatory molecules by islets. Two of these molecules (monocyte
chemoattractant protein-1, CCL2/MCP-1 and tissue factor, TF) are directly correlated with ... Cited by 14 - Related articles - BL Direct - All 4 versions
J Avila, B Barbaro, A Gangemi, T Romagnoli, J … - American Journal of …, 2005 - ccmjournal.org Oxidative stress during islet isolation induces a cascade of events injuring islets and hampering
islet engraftment. This study evaluated islet isolation and transplantation outcomes after
intra-ductal glutamine administration. Human pancreata deemed unsuitable for pancreas ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in the islets of Langerhans
involving activation of apoptosis and necrosis and the production of proinflammatory molecules
that negatively influence islet yield and function and may produce detrimental effects after ... Cited by 72 - Related articles - BL Direct - All 4 versions
