JF Paulsson, GT Westermark - Diabetes, 2005 - Am Diabetes Assoc The amyloid present in the islets of Langerhans in type 2 diabetes is
polymerized islet amyloid polypeptide (IAPP). The precursor protein proIAPP is
posttranslationally modified, a process involving the removal of NH 2 - and ... Cited by 25 - Related articles - All 5 versions
- ►shouxi.net L Marzban, CJ Rhodes, DF Steiner, L Haataja … - Diabetes, 2006 - Am Diabetes Assoc Islet amyloid, formed by aggregation of islet amyloid polypeptide (IAPP;
amylin), is a pathological characteristic of the pancreas in type 2 diabetes and
may contribute to the progressive loss of β-cells in this disease. We ... Cited by 18 - Related articles - BL Direct - All 5 versions
JF Paulsson, A Andersson, P Westermark, GT … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Islet amyloid is a frequent finding in the islets of
Langerhans of individuals with type 2 diabetes. The main amyloid constituent is
the beta cell- derived polypeptide hormone islet amyloid polypeptide ... Cited by 16 - Related articles - BL Direct - All 3 versions
L Marzban, G Trigo-Gonzalez, X Zhu, CJ … - Diabetes, 2004 - Am Diabetes Assoc Islet amyloid polypeptide (IAPP) (amylin), the major component of islet amyloid,
is produced by cleavage at the COOH- and NH 2 -termini of its precursor,
proIAPP, likely by the β-cell prohormone convertases (PC) 1/3 and PC2. ... Cited by 29 - Related articles - BL Direct - All 5 versions
GT Westermark, P Westermark, C Berne, O … - New England Journal of Medicine, 2008 - content.nejm.org To the Editor: We report on a patient with type 1 diabetes mellitus, diagnosed
at 16 years of age, in whom widespread amyloid deposits developed many years
later in transplanted human islets. The islets were administered through ... Cited by 9 - Related articles - All 3 versions
P Westermark, DL Eizirik, DG Pipeleers, C … - Diabetologia, 1995 - Springer Summary Human islets of Langerhans were trans- planted to the subcapsular space
of the kidneys of nude mice which were either normoglycaemic or made diabetic
with alloxan. After 2 weeks, the trans- plants were processed for light and ... Cited by 36 - Related articles - BL Direct - All 5 versions
GT Westermark, DF Steiner, S Gebre-Medhin, … - Upsala journal of medical sciences, 2000 - ncbi.nlm.nih.gov Islet amyloid is typically found in type 2 diabetes mellitus and is believed to
participate in the beta cell deterioration. The islet amyloid fibril consists of
the 37-amino-acid islet amyloid polypeptide (IAPP) but its pathogenesis is ... Cited by 18 - Related articles - BL Direct - All 2 versions
- ►nih.gov S Zraika, RL Hull, J Udayasankar, KM … - Biochemical and biophysical research communications, 2007 - Elsevier Islet amyloid contributes to the loss of β-cell mass in type 2 diabetes. To
examine the roles of glucose and time on amyloid formation, we developed a rapid
in vitro model using isolated islets from human islet amyloid polypeptide ... Cited by 12 - Related articles - All 6 versions
- ►endojournals.org L Marzban, G Trigo-Gonzalez, CB Verchere - Molecular Endocrinology, 2005 - Endocrine Soc Islet amyloid is a pathologic characteristic of the pancreas in type 2 diabetes
comprised mainly of the ß-cell peptide islet amyloid polypeptide (IAPP;
amylin). We used a pulse-chase approach to investigate the kinetics of ... Cited by 6 - Related articles - BL Direct - All 4 versions
F Johan… - Experimental Diabetes Research, 2008 - hindawi.com Amyloid formation is cytotoxic and can activate the caspase cascade. Here, we
monitor caspase-3-like activity as reduction of fluorescence resonance energy
transfer (FRET) using the contstruct pFRET2-DEVD containing enhanced cyan ... Cited by 6 - Related articles - Cached - All 8 versions
