JB Maxhimer, M Somenek, G Rao, CE Pesce, D … - Diabetes, 2005 - Am Diabetes Assoc The molecular mechanisms of heparan sulfate proteoglycan downregulation in the glomerular
basement membrane (GBM) of the kidneys with diabetic nephropathy remain controversial. In
the present study, we showed that the expression of heparanase-1 (HPR1), a heparan ... Cited by 43 - Related articles - All 5 versions
- ►asnjournals.org V Levidiotis, C Freeman, C Tikellis, ME … - Journal of the American …, 2004 - Am Soc Nephrol Heparan sulfate proteoglycans (HSPG) are ubiquitous macromolecules associated with cell
surfaces and extracellular matrix and are one of the major constituents of the glomerular basement
membrane (GBM) (1). They are synthesized by podocytes (2) and endothelial cells (3) ... Cited by 39 - Related articles - BL Direct - All 5 versions
MJ Van Den Hoven, AL Rops, MA Bakker, J Aten, N … - Kidney international, 2006 - nature.com In overt diabetic nephropathy (DNP), an increase in the permeability of the glomerular basement
membrane (GBM) has been associated with a loss of negatively charged heparan sulfates
(HS) in the GBM. Heparanase (HPSE), an endo- (1-4)-D-glucuronidase, can cleave HS ... Cited by 24 - Related articles - BL Direct - All 7 versions
A Katz, DJ Van-Dijk, H Aingorn, A Erman, M Davies, D … - IMAJ-RAMAT GAN-, 2002 - ima.org.il Departments of 1 Pediatrics and 2 Nephrology, Bikur Holim Hospital, Jerusalem, Israel 3 Nephrology
Unit, Rabin Medical Center (Beilinson Campus), Petah Tiqva, Israel 4 Department of
Oncology, Hadassah-Hebrew University Hospital, Jerusalem, Israel 5 Institute of ... Cited by 37 - Related articles - View as HTML - BL Direct - All 2 versions
- ►asnjournals.org V Levidiotis, C Freeman, M Punler, P … - Journal of the American …, 2004 - Am Soc Nephrol The -D-endoglycosidase heparanase has been proposed to be important in the pathogenesis
of proteinuria by acting to selectively degrade the negatively charged side chains of heparan
sulfate proteoglycans (HSPG) within the glomerular basement membrane (GBM). A loss ... Cited by 28 - Related articles - BL Direct - All 7 versions
V Levidiotis, C Freeman, C Tikellis, ME Cooper, DA … - Nephrology, 2005 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 18 - Related articles - All 3 versions
- ►asnjournals.org A Kramer, M van den Hoven, A Rops, T … - Journal of the American …, 2006 - Am Soc Nephrol Heparan sulfate (HS) in the glomerular basement membrane (GBM) is important for regulation
of the charge-dependent permeability. Heparanase has been implicated in HS degradation in
several proteinuric diseases. This study analyzed the role of heparanase in HS ... Cited by 21 - Related articles - BL Direct - All 8 versions
V Levidiotis, J Kanellis, FL Ierino, DA Power - Kidney international, 2001 - nature.com A rabbit polyclonal antibody was produced against a 17-amino acid peptide derived from the
predicted amino acid sequence of heparanase. The antibody was validated by Western blot.
Immunohistochemical staining and Western blotting were used to localize heparanase ... Cited by 46 - Related articles - BL Direct - All 4 versions
J van den Born, B Pisa, MAH Bakker, JWAM Celie, … - Journal of Biological …, 2006 - ASBMB Heparan sulfate (HS) proteoglycans are major anionic glycoconjugates of the glomerular basement
membrane and are thought to contribute to the permeability properties of the glomerular capillary
wall. In this study we evaluated whether the development of (micro) albuminuria in early ... Cited by 19 - Related articles - All 6 versions
- ►asnjournals.org TJM Wijnhoven, JFM Lensen, RGP Wismans, … - Journal of the American …, 2007 - Am Soc Nephrol Heparan sulfates (HS) are long, unbranched, negatively charged polysaccharides that are bound
to core proteins. HS in the glomerular basement membrane (GBM) is reported to be important
for charge-selective permeability. Aberrant GBM HS expression has been observed in ... Cited by 21 - Related articles - BL Direct - All 8 versions
