- ►shouxi.net RL Hull, ZP Shen, MR Watts, K Kodama, DB … - Diabetes, 2005 - Am Diabetes Assoc Islet amyloid deposition in type 2 diabetes is associated with reduced β-cell
mass. Therefore, interventions aimed at reducing islet amyloid formation may
help preserve β-cell mass in type 2 diabetes. Rosiglitazone and metformin ... Cited by 23 - Related articles - All 6 versions
- ►nih.gov S Zraika, RL Hull, J Udayasankar, KM … - Biochemical and biophysical research communications, 2007 - Elsevier Islet amyloid contributes to the loss of β-cell mass in type 2 diabetes. To
examine the roles of glucose and time on amyloid formation, we developed a rapid
in vitro model using isolated islets from human islet amyloid polypeptide ... Cited by 12 - Related articles - All 6 versions
- ►diabetesjournals.org RL Hull, S Andrikopoulos, CB Verchere, J … - Diabetes, 2003 - Am Diabetes Assoc Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide
(hIAPP) in their islet β-cells are a model of islet amyloid formation as it
occurs in type 2 diabetes. Our hIAPP transgenic mice developed islet ... Cited by 37 - Related articles - BL Direct - All 7 versions
F Wang, RL Hull, J Vidal, M Cnop, SE Kahn - Diabetes, 2001 - Am Diabetes Assoc Islet amyloid occurs in >90% of type 2 diabetic patients and may play a role in
the pathogenesis of this disease. To determine whether islet amyloid occurs
diffusely throughout the pancreas, whether it affects islets equally, and ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►shouxi.net JF Paulsson, GT Westermark - Diabetes, 2005 - Am Diabetes Assoc The amyloid present in the islets of Langerhans in type 2 diabetes is
polymerized islet amyloid polypeptide (IAPP). The precursor protein proIAPP is
posttranslationally modified, a process involving the removal of NH 2 - and ... Cited by 25 - Related articles - All 5 versions
- ►endojournals.org CY Lin, T Gurlo, L Haataja, WA Hsueh, PC … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Methods and Results: Vehicle or h-IAPP was applied to human islets with or
without RSG (10 and 50 µM) for 48 h. A 2-fold increase in the number of
terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick end labeling- ... Cited by 36 - Related articles - BL Direct - All 4 versions
JF Paulsson, A Andersson, P Westermark, GT … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Islet amyloid is a frequent finding in the islets of
Langerhans of individuals with type 2 diabetes. The main amyloid constituent is
the beta cell- derived polypeptide hormone islet amyloid polypeptide ... Cited by 16 - Related articles - BL Direct - All 3 versions
- ►physiology.org AR Diani, G Sawada, B Wyse, FT Murray, M … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Thiazolidinediones may slow the progression of type 2 diabetes by preserving
pancreatic -cells. The effects of pioglitazone (PIO) on structure and function
of -cells in KKA(y), C57BL/6J ob/ob, and C57BL/KsJ db/db mice (genetic ... Cited by 57 - Related articles - BL Direct - All 4 versions
Y Li, AN Han-Xiang, D Xiu-Ling, C Lu-Lu, LI … - Acta Pharmacol Sin, 2003 - chinaphar.com Type 2 diabetes mellitus is characteristic by impaired insulin secretion and
diminished peripheral insulin sensitivity. Continuing loss of -cell function is
the underlying cause of deteriorating metabolic control in people with type ... Cited by 17 - Related articles - Cached - BL Direct - All 5 versions
DLA MacArthur, EJP De Koning, JS Verbeek, … - Diabetologia, 1999 - Springer Amyloid deposits are found in the islets of Langer- hans of up to 96% of
patients with Type II (non-insu- lin-dependent) diabetes mellitus [1, 2] but the
rela- ... Amyloid fibril formation is progressive and correlates with ... Cited by 17 - Related articles - BL Direct - All 4 versions
