- ►shouxi.net AP Coll, BG Challis, M López, S Piper, GSH Yeo … - Diabetes, 2005 - Am Diabetes Assoc Congenital lack of proopiomelanocortin (POMC) causes obesity and glucocorticoid
deficiency. The responses of Pomc −/− and wild-type mice to the
administration of corticosterone were compared. In study 1, mice were given ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►nih.gov JL Smart, V Tolle, MJ Low - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Null mutations of the proopiomelanocortin gene (Pomc –/– ) cause obesity in
humans and rodents, but the contributions of central versus pituitary POMC
deficiency are not fully established. To elucidate these roles, we ... Cited by 26 - Related articles - BL Direct - All 12 versions
- ►endocrinology-journals.org AP Coll, M Fassnacht, S Klammer, S Hahner, DM … - Journal of Endocrinology, 2006 - Soc Endocrinology Pro-opiomelanocortin (POMC) is a polypeptide precursor that undergoes extensive
processing to yield a range of peptides with biologically diverse functions.
POMC-derived ACTH is vital for normal adrenal function and the melanocortin ... Cited by 7 - Related articles - BL Direct - All 5 versions
- ►endojournals.org AP Coll, BG Challis, GSH Yeo, K Snell, SJ … - Endocrinology, 2004 - Endocrine Soc The mature adrenal cortex is dependent upon proopiomelanocortin (POMC)-derived
peptides for the maintenance of its size, structure, and endocrine function.
Recent studies in mice genetically deficient in POMC have suggested that ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►endojournals.org YC Tung, SJ Piper, D Yeung, S O'Rahilly, AP … - Endocrinology, 2006 - Endocrine Soc Functional disruption of either MC3R or MC4R results in obesity, implicating
both in the control of energy homeostasis. The ligands for these receptors are
derived from the prohormone proopiomelancortin (POMC), which is ... Cited by 10 - Related articles - BL Direct - All 3 versions
BG Challis, AP Coll, GSH Yeo, SB Pinnock, SL … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Mice lacking pro-opiomelanocortin are sensitive to ... BG Challis* † , AP
Coll* † , GSH Yeo*, SB Pinnock ‡ , SL Dickson ‡ , RR Thresher § , J.
Dixon § , D. Zahn § , ... JJ Rochford*, A. White ¶ , RL Oliver ¶ , G. ... Cited by 147 - Related articles - BL Direct - All 6 versions
- ►endocrinology-journals.org Z Michailidou, AP Coll, CJ Kenyon, NM … - Journal of Endocrinology, 2007 - Soc Endocrinology Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia
of hypothalamic origin. However, low glucocorticoid levels caused by adrenal
insufficiency mitigate against insulin resistance, hyperphagia and fat ... Cited by 2 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org IS Farooqi, S Drop, A Clements, JM Keogh, J … - Diabetes, 2006 - Am Diabetes Assoc Congenital deficiency of proopiomelanocortin (POMC) results in a syndrome of
hypoadrenalism, severe obesity, and altered skin and hair pigmentation. The
concept that subtle variation in POMC expression and/or function might ... Cited by 38 - Related articles - BL Direct - All 6 versions
- ►endojournals.org JL Smart, V Tolle, V Otero-Corchon, MJ Low - Endocrinology, 2007 - Endocrine Soc Proopiomelanocortin (POMC) is synthesized predominantly in pituitary
corticotrophs, melanotrophs, and arcuate hypothalamic neurons.
Corticotroph-derived ACTH mediates basal and stress-induced glucocorticoid ... Cited by 4 - Related articles - BL Direct - All 4 versions
WO Richter, P Schwandt - Metabolism: clinical and experimental, 1985 - ncbi.nlm.nih.gov The proopiocorticomelanotropin (POMC) sequence beta-lipotropin stimulates
glycerol release from incubated rabbit adipocytes at a minimal concentration of
10(-9) mol/L. However, when lipolysis inhibiting substances (eg, fatty ... Cited by 6 - Related articles - All 2 versions
