- ►diabetesjournals.org TL Jetton, J Lausier, K LaRock, WE Trotman, … - Diabetes, 2005 - Am Diabetes Assoc The physiological mechanisms underlying the compensatory growth of β-cell mass
in insulin-resistant states are poorly understood. Using the insulin-resistant
Zucker fatty (fa/fa) (ZF) rat and the corresponding Zucker lean control ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►shouxi.net TL Jetton, J Lausier, K LaRock, WE Trotman, … - DIABETES, 2005 - Am Diabetes Assoc The physiological mechanisms underlying the compen- satory growth of -cell mass
in insulin-resistant states are poorly understood. Using the insulin-resistant
Zucker fatty (fa/fa) (ZF) rat and the corresponding Zucker lean control ... Related articles - All 2 versions
- ►endojournals.org GW Van Citters, M Kabir, SP Kim, SD … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc We previously developed a canine model of central obesity and insulin resistance
by supplementing the normal chow diet with 2 g cooked bacon grease/kg body
weight. Dogs fed this fatty diet maintained glucose tolerance with ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org N Kaiser, R Nesher, MY Donath, M Fraenkel, V … - Diabetes, 2005 - Am Diabetes Assoc Type 2 diabetes is characterized by insulin resistance and progressive ß-cell
failure. Deficient insulin secretion, with increased proportions of insulin
precursor molecules, is a common feature of type 2 diabetes; this could ... Cited by 26 - Related articles - BL Direct - All 6 versions
- ►endojournals.org AH Minn, H Lan, ME Rabaglia, DM Harlan, BA … - Molecular Endocrinology, 2005 - Endocrine Soc Type 2 diabetes occurs when pancreatic ß-cells become unable to compensate for
the underlying insulin resistance. Insulin secretion requires ß-cell insulin
stores to be replenished by insulin biosynthesis, which is mainly regulated ... Cited by 16 - Related articles - All 8 versions
- ►jbc.org P Lebrun, MR Montminy, E Van Obberghen - Journal of Biological Chemistry, 2005 - ASBMB The transcription factor PDX-1 plays a crucial role during pancreatic
development and in the function of insulin-producing beta cells. Disruption of
the pdx-1 gene in these cells induces overt diabetes in mice, and this gene ... Cited by 22 - Related articles - BL Direct - All 5 versions
YQ Liu, TL Jetton, JL Leahy - Journal of Biological Chemistry, 2002 - ASBMB The β-cell biochemical mechanisms that account for the compensatory
hyperfunction with insulin resistance (so-calledβ-cell adaptation) are unknown.
We investigated glucose metabolism in isolated islets from 10–12-week-old ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►physiology.org S Srinivasan, E Bernal-Mizrachi, M Ohsugi, … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc The concentration of glucose in plasma is an important determinant of pancreatic
-cell mass, whereas the relative contributions of hypertrophy, proliferation,
and cell survival to this process are unclear. Glucose results in ... Cited by 62 - Related articles - BL Direct - All 5 versions
TL Jetton, YQ Liu, WE Trotman, PW Nevin, XJ … - Diabetologia, 2001 - Springer The pancreatic beta cell regulates both the storage and metabolism of cellular
fuels through secretion of insulin. Our studies and those of others have shown
an enhanced number of beta cells in response to im- Cited by 37 - Related articles - BL Direct - All 3 versions
