- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM … - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance is predominantly characterized by decreased
insulin-stimulated glucose uptake into skeletal muscle. In the current study, we
have assessed various aspects of the phosphatidylinositol (PI) 3-kinase ... Cited by 80 - Related articles - BL Direct - All 5 versions
- ►jbc.org LA Barbour, M Rahman… - Journal of Biological Chemistry, 2005 - ASBMB Insulin resistance is a cardinal feature of normal pregnancy and excess growth
hormone (GH) states, but its underlying mechanism remains enigmatic. We
previously found a significant increase in the p85 regulatory subunit of ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►endojournals.org JP Kirwan, A Varastehpour, M Jing, L Presley … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc The restoration of maternal insulin sensitivity postpartum represents an
important physiological and metabolic adaptation in a woman's reproductive
lifespan. The present study was conducted to examine the potential cellular ... Cited by 32 - Related articles - BL Direct - All 4 versions
MA Cornier, DH Bessesen, I Gurevich, JW … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: We sought to define early molecular alterations
associated with nutritionally induced insulin resistance in humans. Methods:
Insulin sensitivity was assessed using a hyperinsulinaemic–euglycaemic ... Cited by 15 - Related articles - BL Direct - All 3 versions
K Ueki, DA Fruman, CM Yballe, M Fasshauer, … - Journal of Biological Chemistry, 2003 - ASBMB Class IA phosphoinositide (PI) 3-kinase is composed of a p110 catalytic subunit
and a p85 regulatory subunit and plays a pivotal role in insulin signaling. To
explore the physiological roles of two major regulatory isoforms, p85 and ... Cited by 87 - Related articles - BL Direct - All 5 versions
- ►nih.gov F Mauvais-Jarvis, K Ueki, DA Fruman, MF … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig A critical component of insulin action is the enzyme phosphoinositide (PI)
3-kinase. The major regulatory subunits of PI 3-kinase, p85α and its splice
variants, are encoded by the Pik3r1 gene. Heterozygous disruption of Pik3r1 ... Cited by 152 - Related articles - BL Direct - All 9 versions
- ►endojournals.org LA Barbour, J Shao, L Qiao, W Leitner, M … - Endocrinology, 2004 - Endocrine Soc The insulin resistance of normal pregnancy is necessary to divert fuels to the
fetus to meet fetal growth demands and is mediated by placental hormones. We
recently demonstrated that human placental GH (hPGH) can trigger severe ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►nih.gov K Ueki, P Algenstaedt, F Mauvais-Jarvis, CR … - Molecular and Cellular Biology, 2000 - Am Soc Microbiol Phosphoinositide (PI) 3-kinase is a key mediator of insulin-dependent metabolic
actions, including stimulation of glucose transport and glycogen synthesis. The
gene for the p85 regulatory subunit yields three splicing variants, p85 , ... Cited by 88 - Related articles - BL Direct - All 5 versions
J Luo, SJ Field, JY Lee, JA Engelman, LC … - Journal of Cell Biology, 2005 - jcb.rupress.org Phosphoinositide (PI) 3-kinase is required for most insulin and insulin-like
growth factor (IGF) 1–dependent cellular responses. The p85 regulatory subunit
of PI 3-kinase is required to mediate the insulin-dependent recruitment of ... Cited by 52 - Related articles - BL Direct - All 10 versions
- ►nih.gov D Chen, F Mauvais-Jarvis, M Bluher, SJ … - Molecular and Cellular Biology, 2004 - Am Soc Microbiol Class Ia phosphoinositide (PI) 3-kinases are heterodimers composed of a
regulatory and a catalytic subunit and are essential for the metabolic actions
of insulin. In addition to p85 and p85ß, insulin-sensitive tissues such as ... Cited by 54 - Related articles - BL Direct - All 5 versions
