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Preconditioning the Diabetic Heart

- diabetesjournals.org
A Tsang, DJ Hausenloy, MM Mocanu, RD Carr, DM … - Diabetes, 2005 - Am Diabetes Assoc
Conflicting evidence exists whether diabetic myocardium can be protected by ischemic preconditioning
(IPC). The phosphatidylinositol 3-kinase (PI3K)-Akt pathway is important in IPC. However, components
of this cascade have been found to be defective in diabetes. We hypothesize that IPC in ...
Related articles - All 3 versions

Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic …

- endojournals.org
TL Steiler, D Galuska, Y Leng, AV Chibalin, M Gilbert, … - Endocrinology, 2003 - Endocrine Soc
We determined basal and insulin-stimulated responses on signaling intermediates in soleus
skeletal muscle from male Wistar and diabetic Goto-Kakizaki (GK) rats. Rats were infused with
glucose (5 or 20 mM) for 3 h, followed by a continuous infusion of saline or insulin (3 ...
Cited by 18 - Related articles - BL Direct - All 4 versions

Pharmacological Preconditioning in Type 2 Diabetic Rat Hearts: The Roles of …

- nagasaki-u.ac.jp [PDF] 
S Matsumoto, S Cho, S Tosaka, H Ureshino, T … - … Drugs and Therapy, 2009 - Springer
Abstract Purpose The authors examined whether olprinone, a phosphodiesterase type 3
inhibitor, or isoflurane, a volatile anesthetic, could protect the heart against myocardial infarction
in type 2 diabetic rats and whether the underlying mechanisms involve protein kinase C ( ...
Related articles - All 4 versions

Acute diabetes modulates response to ischemia in isolated rat heart


T Ravingerova, R Stetka, K Volkovova, D Pancza, A … - Molecular and Cellular …, 2000 - Springer
Page 1. 143 Molecular and Cellular Biochemistry 210: 143–151, 2000. © 2000 Kluwer Academic
Publishers. Printed in the Netherlands. Acute diabetes modulates response to ischemia in isolated
rat heart Tanya Ravingerova,1 Radovan Stetka,1 Katarina Volkovova,2 Dezider ...
Cited by 18 - Related articles - BL Direct - All 3 versions

Preconditioning the diabetic human myocardium


V Sivaraman, DJ Hausenloy, AM Wynne, … - Journal of Cellular …, 2009 - interscience.wiley.com
It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...
Related articles - All 2 versions

Preconditioning and postconditioning: new strategies for cardioprotection


DJ Hausenloy, DM Yellon - Diabetes, Obesity and Metabolism, 2008 - interscience.wiley.com
Despite optimal therapy, the morbidity and mortality of coronary heart disease (CHD) remains
significant, particularly in patients with diabetes or the metabolic syndrome. New strategies for
cardioprotection are therefore required to improve the clinical outcomes in patients with ...
Cited by 5 - Related articles - All 2 versions

[PDF] CardioprotectiveEffect of IschemicPreconditioning on Ischemia/Reperfusion …


M Chikara, K OGAWA, H TAKATSUKA, R ANZAWA, I … - Jikeikai Med J, 2006 - ir.jikei.ac.jp
Ischemicheart diseaseis significantlymoreprev- alent and more severe in patients with diabetes
mel- litusthaninthenondiabeticpopulation . However, someanimalstudiessuggest that diabeticheartshave
greater resistanceto ischemia,although other studies suggest they have lower resistance . ...
Related articles

Absence of ischemic preconditioning protection in diabetic sheep hearts: role of …


HF del Valle, EC Lascano, JA Negroni, AJ … - Molecular and cellular …, 2003 - Springer
Sarcolemmal ATP-sensitive potassium (KATP) channels have been mentioned to participate
in preconditioning protection. Since these channels are altered in diabetes, it would be possible
that preconditioning does not develop in diabetic (D) hearts. The purpose of this study ...
Cited by 22 - Related articles - BL Direct - All 4 versions

[PDF] Susceptibility to ischemia-induced arrhythmias and the effect of preconditioning in …


T Ravingerova, R Stetka, D Pancza, O Ulicna, A … - PHYSIOLOGICAL …, 2000 - biomed.cas.cz
608 Ravingerová et al. Vol. 49 cardiomyopathy that has been described in various clinical and
experimental settings (Fein et al. 1980, Dhalla et al. 1985, Dubrey et al. 1994). Contractile dysfunction
as well as rhythm disorders are caused by alterations in the cell membrane ion transport ...
Cited by 23 - Related articles - BL Direct - All 4 versions

Influence of diabetic state and that of different sulfonylureas on the size of …


E Nieszner, I Posa, E Kocsis, G Pogatsa, I … - Experimental and …, 2002 - thieme-connect.com
In vivo studies were made in alloxan diabetic and non-diabetic control rabbits to assess if the
effects of preconditioning and sulfonylurea pretreatment with either glibenclamide or glimepiride
(0.05-0.2-0.6 ?mol kg -1 ) influence the extent of the infarcted area caused by one hour ...
Cited by 24 - Related articles - BL Direct - All 4 versions


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