CA Gysemans, L Ladrière, H Callewaert, J Rasschaert, … - Diabetes, 2005 - Am Diabetes Assoc The main focus in studies on the pathogenesis of autoimmune type 1 diabetes has been on the
role of the immune system, with much less attention directed to the target of the immune
assault, namely the insulin-secreting β-cells. β-Cells under inflammatory attack have ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►daegu.ac.kr [PDF] J Rasschaert, D Liu, B Kutlu, AK Cardozo, M Kruhøffer, … - Diabetologia, 2003 - Springer Aims/hypothesis. Viral infections and local production of IFN-γ might contribute to beta-cell
dysfunction/ death in Type 1 Diabetes. Double stranded RNA (dsRNA) accumulates in the cytosol
of viral-infected cells, and exposure of purified rat beta cells to dsRNA (tested in the form ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org HI Callewaert, CA Gysemans, L Ladrière, W D'Hertog, J … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Exposure of β-cells to inflammatory cytokines leads to apoptotic cell death through
the activation of gene networks under the control of specific transcription factors, such as
interferon-γ–induced signal transducer and activator of transcription (STAT)-1. We ... Cited by 14 - Related articles - BL Direct - All 6 versions
- ►daegu.ac.kr [PDF] P Ylipaasto, B Kutlu, S Rasilainen, J Rasschaert, K … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 1510–1522 DOI 10.1007/s00125-005-1839-7 ARTICLE
P. Ylipaasto . B. Kutlu . S. Rasilainen . J. Rasschaert . K. Salmela . H. Teerijoki . O. Korsgren .
R. Lahesmaa . T. Hovi . DL Eizirik . T. Otonkoski . M. Roivainen ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►ulb.ac.be [PDF] P Pirot, DL Eizirik, AK Cardozo - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: A tight control of endoplas- mic reticulum homeostasis is crucial for
beta cell function and survival. We recently described that IL-1β plus IFN-γ deplete endoplasmic
reticulum Ca 2+ stores in beta cells, leading to endoplasmic reticulum stress and ... Cited by 22 - Related articles - BL Direct - All 5 versions
J Rasschaert, L Ladrière, M Urbain, Z Dogusan, B … - Journal of Biological …, 2005 - ASBMB Viral infections and local production of cytokines probably contribute to the pathogenesis of Type
1 diabetes. The viral replicative intermediate double-stranded RNA (dsRNA, tested in the form
of polyinosinic-polycytidylic acid, PIC), in combination with the cytokine interferon-γ ... Cited by 41 - Related articles - BL Direct - All 5 versions
- ►endojournals.org F Ortis, AK Cardozo, D Crispim, J Storling, T … - Molecular …, 2006 - Endocrine Soc Cytokines, such as IL-1ß and TNF- , contribute to pancreatic ß-cell death in type 1 diabetes
mellitus. The transcription factor nuclear factor- B (NF- B) mediates cytokine-induced ß-cell
apoptosis. Paradoxically, NF- B has mostly antiapoptotic effects in other cell types. The ... Cited by 31 - Related articles - BL Direct - All 6 versions
DL Eizirik, B Kutlu, J Rasschaert, M … - ANNALS-NEW …, 2003 - interscience.wiley.com Abstract: The β cell fate following immune-mediated damage depends on an intricate pattern
of dozens of genes up- or downregulated in parallel and/or sequentially. We are utilizing microarray
analysis to clarify the pattern of gene expression in primary rat β cells exposed to the ... Cited by 32 - Related articles - BL Direct - All 5 versions
CA Gysemans, D Pavlovic, R Bouillon, DL Eizirik, C … - Diabetologia, 2001 - Springer The ability of pancreatic islets to endure assaults of the immune system could be relevant in the
develop- ment of Type I (insulin-dependent) diabetes mellitus. We and other investigators have
suggested that inter- ... Dual role of interferon-g signalling pathway in sensitivity Cited by 17 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Kim, HS Kim, KW Chung, SH Oh, JW Yun, SH Im, MK … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—STAT1 −/− islet cells were resistant to death by interferon (IFN)-γ/tumor necrosis
factor (TNF)-α or IFN-γ/interleukin (IL)-1β combination. Cytochrome c translocation by
IFN-γ/TNF-α was abrogated in STAT1 −/− islet cells. The induction of X-linked inhibitor of ... Cited by 8 - Related articles - BL Direct - All 6 versions
