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Scholar Results 1 - 10 of about 101 related to Okon: Compromised arterial function in human type 2 diabetic patients. (0.13 sec) 

Compromised arterial function in human type 2 diabetic patients


EB Okon, AWY Chung, P Rauniyar, E Padilla, T … - Diabetes, 2005 - Am Diabetes Assoc
Diabetes is associated with a perturbation of signaling pathways in vascular tissue, which causes
vasomotor dysfunction such as hypertension and accelerated atherosclerosis. In the present
study, the mechanisms of vasomotor dysfunction, Akt (Thr 308 and Ser 473 ) ...
Cited by 34 - Related articles - BL Direct - All 5 versions

Augmented contractile response of vascular smooth muscle in a diabetic mouse …


EB Okon, T Szado, I Laher, B McManus, C van … - Journal of Vasc …, 2003 - content.karger.com
The vasomotor properties of isolated aortae and mesenteric arteries of insulin-resistant ob/ob
and 57CBL/6J mice were compared in organ bath studies. Vessels from ob/ob mice were more
sensitive to phenylephrine. Pretreatment with L-NAME caused similar leftward shifts of the ...
Cited by 39 - Related articles - BL Direct - All 5 versions

Human vascular smooth muscle cells from diabetic patients are resistant to …


E Ruiz, A Gordillo-Moscoso, E Padilla, S Redondo, E … - Diabetes, 2006 - Am Diabetes Assoc
An emerging body of evidence suggests that vascular remodeling in diabetic patients involves
a perturbation of the balance between cell proliferation and cell death. Our aim was to study
whether arteries and vascular smooth muscle cells (VSMCs) isolated from diabetic ...
Cited by 11 - Related articles - BL Direct - All 5 versions

Pressure distention compared with pharmacologic relaxation in vein grafting …


AWY Chung, P Rauniyar, H Luo, YN Hsiang, C van … - Journal of Vascular …, 2005 - Elsevier
Autogenous vein bypasses are a common and effective method to treat occlusive disease. During
surgical preparation, veins are routinely pressure distended to overcome vasospasm and
twists. Distention, however, is believed to promote vascular remodeling and contribute to ...
Cited by 17 - Related articles - All 28 versions

Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II …


RAM Schwaninger, H Sun, WG Mayhan - Life sciences, 2003 - Elsevier
The goals of this study were to determine the effects of type II diabetes mellitus on nitric oxide
synthase-dependent responses of cerebral arterioles and on endothelial nitric oxide synthase
(eNOS) protein in cerebral arterioles. We examined dilatation of cerebral (pial) arterioles ...
Cited by 21 - Related articles - All 4 versions

Enhanced role for RhoA-associated kinase in adrenergic-mediated …

- physiology.org
JS Naik, L Xiang, RL Hester - American Journal of Physiology- …, 2006 - Am Physiological Soc
Obesity, insulin resistance, dyslipidemia, and hypertension are components of the pathophysiological
state known as metabolic syndrome. Adrenergic vasoconstriction is mediated through increases
in cytosolic Ca 2+ and the myofilaments' sensitivity to Ca 2+ . In many pathophysiological ...
Cited by 21 - Related articles - BL Direct - All 3 versions

Increased matrix metalloproteinase 2 activity in the human internal mammary artery …


AW Chung, AD Booth, C Rose, CR Thompson, A Levin, … - J Vasc Res, 2008 - content.karger.com
Dysregulation of matrix metalloproteinase (MMP)-2 in the vasculature has been suggested to
be associated with increased prevalence of cardiovascular disease and renal injury. In this descriptive
study, we hypothesized that arterial MMP-2 activity is elevated in the presence of ...
Cited by 6 - Related articles - BL Direct - All 4 versions

Impaired insulin-induced vasodilation in small coronary arteries of Zucker obese …

- physiology.org
PVG Katakam, CD Tulbert, JA Snipes, B … - American Journal of …, 2005 - Am Physiological Soc
Insulin resistance (IR) and associated hyperinsulinemia are major risk factors for coronary artery
disease. Mechanisms linking hyperinsulinemia to coronary vascular dysfunction in IR are
unclear. We evaluated insulin-induced vasodilation in isolated small coronary arteries ...
Cited by 45 - Related articles - All 4 versions

Effects of non-insulin dependent diabetes mellitus on the reactivity of human …


Ç Karasu, H Soncul, VM Altan - Life Sciences, 1995 - Elsevier
The effects of non-insulin-dependent diabetes mellitus (NIDDM) were investigated on the reactivity
of human internal mammary artery (IMA) and saphenous vein (SV) rings obtained from coronary
artery patients (CAP) undergoing coronary artery bypass surgery. In the presence of ...
Cited by 25 - Related articles - BL Direct - All 4 versions

Intensive treatment of risk factors in patients with type-2 diabetes mellitus is …

- oxfordjournals.org
S Yasuda, S Miyazaki, M Kanda, Y Goto, M … - European heart …, 2006 - Eur Soc Cardiology
Methods and results In 24 patients with type-2 DM, the flow-mediated, endothelium-dependent
dilation (FMD: %) of brachial arteries during reactive hyperaemia was determined by a high-resolution
ultrasound method. Blood samples for glucose, cholesterol, TNF- , and ADMA analyses ...
Cited by 25 - Related articles - BL Direct - All 4 versions


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