SY Park, YR Cho, BN Finck, HJ Kim, T Higashimori, EG … - Diabetes, 2005 - Am Diabetes Assoc Diabetic heart failure may be causally associated with alterations in cardiac energy metabolism
and insulin resistance. Mice with heart-specific overexpression of peroxisome proliferator–activated
receptor (PPAR)α showed a metabolic and cardiomyopathic phenotype similar to the ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►physiology.org N Sambandam, D Morabito, C Wagg, BN … - American Journal of …, 2006 - Am Physiological Soc High fatty acid oxidation (FAO) rates contribute to ischemia-reperfusion injury of the
myocardium. Because peroxisome proliferator-activated receptor (PPAR) regulates transcription
of several FAO enzymes in the heart, we examined the response of mice with cardiac- ... Cited by 38 - Related articles - BL Direct - All 2 versions
- ►physiology.org M Panagia, GF Gibbons, GK Radda, K … - American Journal of …, 2005 - Am Physiological Soc The transcription of key metabolic regulatory enzymes in the heart is altered in the diabetic
state, yet little is known of the underlying mechanisms. The aim of this study was to investigate
the role of peroxisome proliferator-activated receptor- (PPAR- ) in modulating cardiac ... Cited by 34 - Related articles - All 5 versions
IS Harris, I Treskov, MW Rowley, S Heximer, K … - Diabetes, 2004 - Am Diabetes Assoc Diabetic patients develop a cardiomyopathy that consists of ventricular hypertrophy and diastolic
dysfunction. Although the pathogenesis of this condition is poorly understood, previous studies
implicated abnormal G-protein activation. In this work, mice with cardiac overexpression ... Cited by 26 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org I Luptak, JA Balschi, Y Xing, TC Leone, DP Kelly, R … - Circulation, 2005 - Am Heart Assoc Methods and Results— We assessed contractile function and substrate utilization using 13 C
nuclear magnetic resonance spectroscopy and high-energy phosphate metabolism using 31
P nuclear magnetic resonance spectroscopy in perfused hearts isolated from genetically ... Cited by 43 - Related articles - All 7 versions
A Ellen, C Marie - Canadian journal of physiology and …, 2005 - ingentaconnect.com Abstract: Peroxisome proliferator-activated receptor-α (PPARα) regulates the expression of fatty
acid (FA) oxidation genes in liver and heart. Although PPARα ligands increased FA oxidation
in cultured cardiomyocytes, the cardiac effects of chronic PPARα ligand administration in ... Cited by 24 - Related articles - All 7 versions
WS Cook, AV Yeldandi, MS Rao, T Hashimoto, JK … - … and Biophysical Research …, 2000 - Elsevier The peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that transcriptionally
regulates mitochondrial and peroxisomal fatty acid β-oxidation enzymes in the liver. Ligands
include synthetic peroxisome proliferators and some fatty acids. PPARα activation leads ... Cited by 41 - Related articles - BL Direct - All 7 versions
BN Finck, X Han, M Courtois, F Aimond, … - Proceedings of the …, 2003 - National Acad Sciences To explore the role of peroxisome proliferator-activated receptor α (PPARα)-mediated derangements
in myocardial metabolism in the pathogenesis of diabetic cardiomyopathy, insulinopenic mice
with PPARα deficiency (PPARα −/− ) or cardiac-restricted overexpression [myosin heavy ... Cited by 210 - Related articles - BL Direct - All 12 versions
- ►oxfordjournals.org HN Sabbaha, WC Stanley - European Journal of Heart Failure, 2002 - Elsevier To meet the high demands of energy by the contracting muscle, the heart must produce a constant
and plentiful supply of ATP, energy that is derived from the metabolism of fatty acids and
carbohydrates. Fatty acids are the preferred substrate of the myocardium, contributing ... Cited by 15 - Related articles - All 4 versions
