- ►shouxi.net A Plesner, P Liston, R Tan, RG Korneluk, CB … - Diabetes, 2005 - Am Diabetes Assoc Allotransplantation of pancreatic islets represents a promising approach to
treat type 1 diabetes. Destruction of β-cells in islet allografts involves
multiple immune mechanisms that lead to activation of caspases and ... Cited by 14 - Related articles - BL Direct - All 6 versions
- ►shouxi.net JA Emamaullee, RV Rajotte, P Liston, RG … - Diabetes, 2005 - Am Diabetes Assoc The Edmonton Protocol for treatment of type 1 diabetes requires islets from two
or more donors to achieve euglycemia in a single recipient, primarily because
soon after portal infusion, the majority of the transplanted cells undergo ... Cited by 24 - Related articles - BL Direct - All 8 versions
J Emamaullee, P Liston, RG Korneluk, AMJ … - Am J Transplant, 2005 - interscience.wiley.com Recent advances in clinical islet transplantation have allowed patients with
type 1 diabetes to become insulin independent, but the procedure is limited
since islets from two donors per recipient are typically required. This ... Cited by 21 - Related articles - All 5 versions
P Cattan, D Rottembourg, S Cottet, I Tardivel, … - Diabetologia, 2003 - Springer Aims/Hypothesis. βTC-tet (H2 k ) is a conditional insu- linoma cell line
derived from transgenic mice express- ing a tetracycline-regulated oncogene.
Transgenic expression of several proteins implicated in the apo- ptotic ... Cited by 4 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Hui, N Khoury, X Zhao, L Balkir, ED'Amico, A … - Diabetes, 2005 - Am Diabetes Assoc Immunosuppressive drugs are routinely used to provide tolerance after whole
pancreas and islet cell transplantations. While they are essential in inhibiting
graft rejection, little is known about their effect on islet function and ... Cited by 32 - Related articles - All 5 versions
- ►shouxi.net TB Mysore, TA Shinkel, J Collins, EJ Salvaris … - Diabetes, 2005 - Am Diabetes Assoc Primary nonfunction of transplanted islets results in part from their
sensitivity to reactive oxygen species (ROS) generated during the isolation and
transplantation process. Our aim was to examine whether coexpression of ... Cited by 27 - Related articles - All 5 versions
JL Contreras, G Bilbao, C Smyth, DE Eckhoff, … - Surgery, 2001 - Elsevier Background. Exposing adult porcine pancreatic islets (PI) to xenoreactive
natural antibodies (XNA) induces brisk inflammatory injury that involves
activation of the complement system. Gene transfer of Bcl-2 has been shown ... Cited by 44 - Related articles - BL Direct - All 11 versions
- ►jimmunol.org ST Grey, C Longo, T Shukri, VI Patel, E … - The Journal of Immunology, 2003 - Am Assoc Immnol Transplantation of an excessive number of islets of Langerhans (two to four
pancreata per recipient) into patients with type I diabetes is required to
restore euglycemia. Hypoxia, nutrient deprivation, local inflammation, and ... Cited by 44 - Related articles - BL Direct - All 4 versions
A Hyder, C Laue, J Schrezenmeir - Toxicology in Vitro, 2005 - Elsevier The success of the new immunosuppressive regime known as the Edmonton protocol
in islet allotransplantation may suggest that it is also possible that this
regime may prevent the rejection of xenografts. This protocol applies a ... Cited by 11 - Related articles - All 4 versions
DA Lepore, TA Shinkel, N Fisicaro, TB … - Xenotransplantation, 2004 - interscience.wiley.com Abstract: The survival of pancreatic islet β–cell xenografts and allografts
may be affected by damaging reactive oxygen and nitrogen species generated
during hypoxia-reoxygenation. Peroxynitrite, which is formed from ... Cited by 11 - Related articles - BL Direct - All 3 versions
