JA Emamaullee, RV Rajotte, P Liston, RG … - Diabetes, 2005 - Am Diabetes Assoc The Edmonton Protocol for treatment of type 1 diabetes requires islets from two
or more donors to achieve euglycemia in a single recipient, primarily because
soon after portal infusion, the majority of the transplanted cells undergo ... Cited by 24 - Related articles - BL Direct - All 8 versions
J Emamaullee, P Liston, RG Korneluk, AMJ … - Am J Transplant, 2005 - interscience.wiley.com Recent advances in clinical islet transplantation have allowed patients with
type 1 diabetes to become insulin independent, but the procedure is limited
since islets from two donors per recipient are typically required. This ... Cited by 21 - Related articles - All 5 versions
A Plesner, P Liston, R Tan, RG Korneluk, CB … - Diabetes, 2005 - Am Diabetes Assoc Allotransplantation of pancreatic islets represents a promising approach to
treat type 1 diabetes. Destruction of β-cells in islet allografts involves
multiple immune mechanisms that lead to activation of caspases and ... Cited by 15 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org H Hui, N Khoury, X Zhao, L Balkir, ED'Amico, A … - Diabetes, 2005 - Am Diabetes Assoc Immunosuppressive drugs are routinely used to provide tolerance after whole
pancreas and islet cell transplantations. While they are essential in inhibiting
graft rejection, little is known about their effect on islet function and ... Cited by 33 - Related articles - All 5 versions
- ►diabetesjournals.org JA Emamaullee, L Stanton, C Schur, AM … - Diabetes, 2007 - Am Diabetes Assoc Islet transplantation can provide insulin independence in patients with type 1
diabetes, but islets derived from two or more donors are often required. A
significant fraction of the functional islet mass is lost to apoptosis in ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JA Emamaullee, AM Shapiro - Diabetes, 2006 - Am Diabetes Assoc A substantial proportion of the transplanted islet mass fails to engraft due to
death by apoptosis, and a number of strategies have been explored to inhibit
β-cell loss. Inhibition of extrinsic signals of apoptosis (ie, cFLIP or ... Cited by 31 - Related articles - BL Direct - All 10 versions
JA Emamaullee, AMJ Shapiro, RV Rajotte, G … - Transplantation, 2006 - journals.lww.com Transplantation. Wolters Kluwer Health Logo. All Issues. ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org ST Grey, C Longo, T Shukri, VI Patel, E … - The Journal of Immunology, 2003 - Am Assoc Immnol Transplantation of an excessive number of islets of Langerhans (two to four
pancreata per recipient) into patients with type I diabetes is required to
restore euglycemia. Hypoxia, nutrient deprivation, local inflammation, and ... Cited by 44 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org J Allison, H Thomas, D Beck, JL Brady, AM … - International Immunology, 2000 - Jpn Soc Immunol Insulin-dependent diabetes mellitus results when > 90% of the insulin-producing
ß cells in the pancreatic islets are killed as a result of autoimmune attack by
T cells. During the progression to diabetes, islet ß cells die as a result ... Cited by 26 - Related articles - BL Direct - All 4 versions
TB Mysore, TA Shinkel, J Collins, EJ Salvaris … - Diabetes, 2005 - Am Diabetes Assoc Primary nonfunction of transplanted islets results in part from their
sensitivity to reactive oxygen species (ROS) generated during the isolation and
transplantation process. Our aim was to examine whether coexpression of ... Cited by 27 - Related articles - All 5 versions
