- ►diabetesjournals.org M Teta, SY Long, LM Wartschow, MM Rankin, … - Diabetes, 2005 - Am Diabetes Assoc Although many signaling pathways have been shown to promote ß-cell growth,
surprisingly little is known about the normal life cycle of preexisting ß-cells
or the signaling pathways required for ß-cell survival. Adult ß-cells ... Cited by 98 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] S Georgia, A Bhushan - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig The endocrine pancreas undergoes major remodeling during neonatal development
when replication of differentiated β cells is the major mechanism by which β
cell mass is regulated. The molecular mechanisms that govern the ... Cited by 165 - Related articles - BL Direct - All 8 versions
- ►upenn.edu [PDF] M Teta, MM Rankin, SY Long, GM Stein, JA … - Developmental cell, 2007 - Elsevier Cellular progenitors remain poorly characterized in many adult tissues, limited
in part by the lack of unbiased techniques to identify progenitors and their
progeny. To address this fundamental problem, we developed a novel DNA ... Cited by 88 - Related articles - All 12 versions
- ►nih.gov JA Kushner, MA Ciemerych, E Sicinska, LM … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol Regulation of adult ß-cell mass in pancreatic islets is essential to preserve
sufficient insulin secretion in order to appropriately regulate glucose
homeostasis. In many tissues mitogens influence development by stimulating ... Cited by 113 - Related articles - All 7 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
DT Finegood, L Scaglia, S Bonner-Weir - Diabetes, 1995 - Am Diabetes Assoc The growth and development of the endocrine pancreas has been studied for many
years, but questions remain concerning the regulation of the mass of
insulin-producing beta-cells both in the normal growing pancreas and during ... Cited by 337 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] E Montanya, V Nacher, M Biarnes, J Soler - Diabetes, 2000 - Am Diabetes Assoc We determined the -cell replicative rate, -cell apo- ptosis, cross-sectional
-cell area, and pancreatic -cell mass throughout the entire postweaning lifespan
(months 1, 3, 7, 10, 15, and 20) of Lewis rats. -Cell replication was ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S Fatrai, L Elghazi, N Balcazar, C Cras- … - Diabetes, 2006 - Am Diabetes Assoc Proliferation is the major component for maintenance of β-cell mass in adult
animals. Activation of phosphoinositide 3-kinase/Akt-kinase pathway is a
critical regulator of β-cell mass. Pancreatic β-cell overexpression of ... Cited by 42 - Related articles - BL Direct - All 5 versions
FA Van Assche, L Aerts, F De Prins - British journal of obstetrics and gynaecology, 1978 - ncbi.nlm.nih.gov 1: Br J Obstet Gynaecol. 1978 Nov;85(11):818-20. A morphological study of the endocrine
pancreas in human pregnancy. Van Assche FA, Aerts L, De Prins F. ... Cited by 48 - Related articles - All 2 versions
JJ Meier, A Bhushan, AE Butler, RA Rizza, PC … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Type 1 diabetes is widely held to result from an
irreversible loss of insulin-secreting beta cells. However, insulin secretion is
detectable in some peo- ple with long-standing type 1 diabetes, indicating ... Cited by 103 - Related articles - BL Direct - All 5 versions
