M Zalzman, L Anker-Kitai, S Efrat - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet insulin-producing
β-cells. Insulin administration does not prevent long-term complications of the disease, as the
optimal insulin dosage is difficult to adjust. Replacement of the damaged cells with ... Cited by 71 - Related articles - BL Direct - All 5 versions
- ►nih.gov T Sapir, K Shternhall, I Meivar-Levy, T … - Proceedings of the …, 2005 - National Acad Sciences Shortage in tissue availability from cadaver donors and the need for life-long immunosuppression
severely restrict the large-scale application of cell-replacement therapy for diabetic patients.
This study suggests the potential use of adult human liver as alternate tissue for ... Cited by 99 - Related articles - All 10 versions
WC Li, ME Horb, D Tosh, JMW Slack - Mechanisms of development, 2005 - Elsevier We have characterised the transdifferentiation of human HepG2 (hepatoma) cells to pancreatic
cells following introduction of an activated version of the pancreatic transcription factor Pdx1
(XlHbox8-VP16). The following questions are addressed: (1) are all types of pancreatic ... Cited by 54 - Related articles - All 6 versions
- ►diabetesjournals.org LZ Cao, DQ Tang, ME Horb, SW Li, LJ Yang - Diabetes, 2004 - Am Diabetes Assoc Pdx1 has been shown to convert hepatocytes into both exocrine and endocrine pancreatic cells
in mice, but it fails to selectively convert hepatocytes into pure insulin-producing cells (IPCs).
The molecular mechanisms underlying the transdifferentiation remain unclear. In this ... Cited by 65 - Related articles - BL Direct - All 6 versions
M Zalzman, S Gupta, RK Giri, I Berkovich, … - Proceedings of the …, 2003 - National Acad Sciences Beta-cell replacement is considered to be the most promising approach for treatment of type
1 diabetes. Its application on a large scale is hindered by a shortage of cells for
transplantation. Activation of insulin expression, storage, and regulated secretion in stem/ ... Cited by 171 - Related articles - BL Direct - All 13 versions
DQ Tang, LZ Cao, BR Burkhardt, CQ Xia, SA Litherland … - Diabetes, 2004 - Am Diabetes Assoc Efforts toward routine islet cell transplantation as a means for reversing type 1 diabetes have
been hampered by islet availability as well as allograft rejection. In vitro transdifferentiation of
mouse bone marrow (BM)-derived stem (mBMDS) cells into insulin-producing cells could ... Cited by 214 - Related articles - BL Direct - All 7 versions
- ►alphamedpress.org S Yoshida, F Ishikawa, N Kawano, K Shimoda, S … - Stem Cells, 2005 - AlphaMed Press Here we report the capacity of human cord blood (CB)–derived cells to generate insulin-producing
cells. To investigate in vivo capacity of human CB–derived cells, T cell–depleted mononuclear
cells were intravenously transplanted into nonobese diabetic/severe combined ... Cited by 30 - Related articles - BL Direct - All 5 versions
I Ber, K Shternhall, S Perl, Z Ohanuna, I Goldberg, I … - Journal of Biological …, 2003 - ASBMB Pancreatic and duodenal homeobox gene-1 (PDX-1) regulates pancreas development during
embryogenesis, whereas in the adult it controls β-cell function. Here we analyze whether
PDX-1 functions as a pancreatic differentiation factor and a bona fide master regulator ... Cited by 106 - Related articles - BL Direct - All 4 versions
J Imai, H Katagiri, T Yamada, Y Ishigaki, T Ogihara, … - … and Biophysical Research …, 2005 - Elsevier To generate insulin-producing cells in the liver, recombinant adenovirus containing a constitutively
active mutant of PDX1 (PDX1-VP16), designed to activate target genes without the need for protein
partners, was prepared and administered intravenously to streptozotocin (STZ)-treated ... Cited by 32 - Related articles - All 4 versions
A Pessina, B Eletti, C Croera, N Savalli, C … - … and Biophysical Research …, 2004 - Elsevier Haematopoietic system represents the main source of haematopoietic stem cells and probably
of multipotential adult progenitor cells and mesenchimal stem cells at first described as colony
forming unit-fibroblast. Whereas there are many studies on the gene expression profile of ... Cited by 33 - Related articles - All 4 versions
