- ►diabetesjournals.org AM Holland, LJ Góñez, G Naselli, RJ … - Diabetes, 2005 - Am Diabetes Assoc The homeodomain transcription factor Pdx1 is essential for pancreas development.
To investigate the role of Pdx1 in the adult pancreas, we employed a mouse model
in which transcription of Pdx1 could be reversibly repressed by ... Cited by 38 - Related articles - BL Direct - All 5 versions
MA Hale, H Kagami, L Shi, AM Holland, HP … - Developmental Biology, 2005 - Elsevier The homeoprotein PDX1 is expressed throughout pancreatic development and is
thought to play important roles at multiple stages. We describe the properties
of a tet-off regulatory scheme to manage the expression of Pdx1 in utero. ... Cited by 31 - Related articles - All 3 versions
- ►pnas.org AM Holland, MA Hale, H Kagami, RE Hammer … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences To investigate the role of the HOX-like homeoprotein PDX1 in the formation and
maintenance of the pancreas, we have genetically engineered mice so that the
only source of PDX1 is a transgene that can be controlled by the ... Cited by 88 - Related articles - BL Direct - All 13 versions
H Noguchi, M Matsushita, S Matsumoto, YF Lu … - Biochemical and Biophysical Research …, 2005 - Elsevier PDX-1 plays a central role in differentiation of insulin-producing cells. We
previously reported that exogenous PDX-1 protein can permeate cells and induce
insulin gene expression in progenitor cells. These data suggest a strategy ... Cited by 26 - Related articles - All 6 versions
- ►ukpmc.ac.uk Y Fujitani, S Fujitani, DF Boyer, M Gannon, … - Genes & development, 2006 - genesdev.cshlp.org Pdx1 (IPF-1 in humans, which is altered in MODY-4) is essential for pancreas
development and mature β-cell function. Pdx1 is expressed dynamically within
the developing foregut, but how its expression characteristics are linked ... Cited by 37 - Related articles - BL Direct - All 12 versions
T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, … - Biochemical and Biophysical Research …, 2003 - Elsevier To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in
inducing differentiation into insulin-producing cells has been demonstrated in
some cells and tissues. In order to carry out efficient screening of ... Cited by 46 - Related articles - All 6 versions
- ►diabetesjournals.org H Kaneto, Y Nakatani, T Miyatsuka, T … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is the most prevalent and serious metabolic disease, and the number of
diabetic patients worldwide is increasing. The reduction of insulin biosynthesis
in pancreatic β-cells is closely associated with the onset and progression ... Cited by 51 - Related articles - All 6 versions
J Imai, H Katagiri, T Yamada, Y Ishigaki, T … - Biochemical and Biophysical Research …, 2005 - Elsevier To generate insulin-producing cells in the liver, recombinant adenovirus
containing a constitutively active mutant of PDX1 (PDX1-VP16), designed to
activate target genes without the need for protein partners, was prepared ... Cited by 32 - Related articles - All 4 versions
S Yamada, Y Yamamoto, M Nagasawa, A Hara, … - Endocrine journal, 2006 - ncbi.nlm.nih.gov Adenovirus-mediated gene transfer of pancreatic duodenal homeobox transcription
factor PDX-1, especially its super-active version (PDX-1/VP16), induces the
expression of pancreatic hormones in murine liver and reverses ... Cited by 14 - Related articles - BL Direct - All 3 versions
[CITATION] Persistent expression of PDX-1 causes acinar-to-ductal transition through Stat3 activation
