- ►diabetesjournals.org JC Koster, MS Remedi, C Dao, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The prediction that overactivity of the pancreatic ATP-sensitive K + channel (K
ATP channel) underlies reduced insulin secretion and causes a diabetic phenotype
in humans has recently been borne out by genetic studies implicating ... Cited by 34 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org P Proks, C Girard, FM Ashcroft - Human Molecular Genetics, 2005 - Oxford Univ Press Recent studies have shown that heterozygous mutations in KCNJ11, which encodes
Kir6.2, the pore-forming subunit of the ATP-sensitive potassium (K ATP )
channel, cause permanent neonatal diabetes either alone (R201C, R201H) or ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►nih.gov P Proks, JF Antcliff, J Lippiat, AL Gloyn, AT … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Inwardly rectifying potassium channels (Kir channels) control cell membrane K +
fluxes and electrical signaling in diverse cell types. Heterozygous mutations in
the human Kir6.2 gene (KCNJ11), the pore-forming subunit of the ... Cited by 115 - Related articles - All 11 versions
A Zung, B Glaser, R Nimri, Z Zadik - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Permanent neonatal diabetes mellitus (PNDM) is a rare form of diabetes
characterized by insulin-requiring hyperglycemia that is diagnosed within the
first months of life. Recently, activating mutations in the gene encoding ... Cited by 94 - Related articles - BL Direct - All 5 versions
SE Flanagan, EL Edghill, AL Gloyn, S Ellard, … - Diabetologia, 2006 - Springer Mutations in KCNJ11, which encodes Kir6.2, are a common cause ... Received: 3
November 2005 / Accepted: 28 February 2006 / Published online: 12 April 2006 #
Springer-Verlag 2006 ... Abstract Aims/hypothesis: Heterozygous ... Cited by 75 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org AL Gloyn, F Reimann, C Girard, EL Edghill, P … - Human molecular genetics, 2005 - Oxford Univ Press Neonatal diabetes can either remit and hence be transient or else may be
permanent. These two phenotypes were considered to be genetically distinct.
Abnormalities of 6q24 are the commonest cause of transient neonatal ... Cited by 89 - Related articles - All 7 versions
- ►diabetesjournals.org JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The ATP-sensitive K + channel (K ATP channel) senses metabolic changes in the
pancreatic β-cell, thereby coupling metabolism to electrical activity and
ultimately to insulin secretion. When K ATP channels open, β-cells ... Cited by 43 - Related articles - BL Direct - All 5 versions
CW Lin, YW Lin, FF Yan, J Casey, M Kochhar, … - Diabetes, 2006 - Am Diabetes Assoc Heterozygous missense mutations in the pore-forming subunit Kir6.2 of
ATP-sensitive K + channels (K ATP channels) have recently been shown to cause
permanent neonatal diabetes mellitus (PNDM). Functional studies ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►endojournals.org T Yorifuji, K Nagashima, K Kurokawa, M … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Context: Known genes in maturity-onset diabetes of the young account for only a
fraction of families with dominantly inherited diabetes in Japan. There should
be as-yet-unidentified genes that account for the rest of the patients. Cited by 40 - Related articles - All 6 versions
W Trust - Human mutation - interscience.wiley.com Permanent neonatal diabetes mellitus (PNDM) is a rare condition characterized by
severe hyperglycemia constantly requiring insulin treatment from its onset.
Complete deficiency of glucokinase (GCK) can cause PNDM; however, the ... Cited by 70 - Related articles - All 4 versions
