- ►nih.gov [PDF] N Feng, SF Young, G Aguilera, E Puricelli, … - Diabetes, 2005 - Am Diabetes Assoc Both human linkage studies and MC3R knockout mouse models suggest that the MC3R
may play an important role in energy homeostasis. Here we show that among 355
overweight and nonoverweight children, 8.2% were double homozygous for a ... Cited by 30 - Related articles - BL Direct - All 7 versions
- ►endojournals.org EH Hani, S Dupont, E Durand, C Dina, S … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc Familial genetic studies of type 2 diabetes (T2DM) of different human
populations, including the French Caucasians, suggested evidence for linkage of
T2DM and human chromosome 20q13, a region where maps the melanocortin 3 ... Cited by 29 - Related articles - All 5 versions
- ►diabetesjournals.org S Lee… - Diabetes, 2007 - Am Diabetes Assoc RESULTS—In vitro functional studies of the resultant mutant receptors revealed
impaired signaling activity but normal ligand binding and cell surface
expression. The heterozygotes demonstrated higher leptin levels and ... Cited by 11 - Related articles - BL Direct - All 4 versions
C Schalin-Jäntti, K Valli-Jaakola, L Oksanen, … - International Journal of Obesity, 2003 - nature.com SUBJECTS AND METHODS: MC3R coding and 5 ' -flanking regions were sequenced in 48
subjects and the detected variants genotyped in 252 morbidly obese (BMI 40 kg/m
2 ) Finns. Gel shifts were used to examine whether a mutation in the ... Cited by 33 - Related articles - BL Direct - All 5 versions
WD Li, EJ Joo, EB Furlong, M Galvin, K Abel, … - International journal of obesity, 2000 - cat.inist.fr OBJECTIVE: Following several reports of linkage of obesity related phenotypes to
human chromosome 20 q we sought to determine whether variations of the
melanocortin 3 receptor(MC 3 R) gene are associated with obesity. DESIGN: ... Cited by 39 - Related articles - BL Direct - All 2 versions
- ►endojournals.org YX Tao, DL Segaloff - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Although melanocortin-4 receptor mutations are the cause of the most common
monogenic form of obesity, the involvement of the melanocortin-3 receptor (MC3R)
in the pathogenesis of obesity is unknown. Earlier studies failed to ... Cited by 25 - Related articles - BL Direct - All 8 versions
- ►ajcn.org N Santoro, L Perrone, G Cirillo, P Raimondo, … - American Journal of Clinical Nutrition, 2007 - Am Soc Nutrition Background:The central melanocortin system is critical for the long-term
regulation of energy homeostasis. Melanocortin-3 receptor (MC3R) knock-out mice,
despite being hypophagic, have increased fat mass and higher feed ... Cited by 20 - Related articles - BL Direct - All 7 versions
J Wong, DR Love, C Kyle, A Daniels, M White … - Diabetes research and clinical practice, 2002 - Elsevier Genetic studies suggest a diabetes susceptibility locus on human chromosome 20,
near the melanocortin receptor-3 (MC3-R) gene. We examined the MC3-R as a
candidate gene for type 2 diabetes in 12 members of a large Maori kindred ... Cited by 16 - Related articles - All 11 versions
M Rached, A Buronfosse, M Begeot, A … - BBA-Molecular Basis of Disease, 2004 - Elsevier Melanocortins are known to be involved in the regulation of feeding behavior.
These hormones mediate their effects through G protein-coupled receptors (GPCRs)
by stimulating adenylate cyclase. The melanocortin 3 receptor (MC3R) in the ... Cited by 18 - Related articles - All 3 versions
