F Tremblay, M Krebs, L Dombrowski, A Brehm, E … - Diabetes, 2005 - Am Diabetes Assoc To examine the molecular mechanisms by which plasma amino acid elevation impairs insulin
action, we studied seven healthy men twice in random order during infusion of an amino acid
mixture or saline (total plasma amino acid ∼6 vs. ∼2 mmol/l). ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Khamzina, A Veilleux, S Bergeron, A Marette - Endocrinology, 2005 - Endocrine Soc The mammalian target of rapamycin (mTOR) pathway integrates insulin and nutrient signaling
in numerous cell types. Recent studies also suggest that this pathway negatively modulates insulin
signaling to phosphatidylinositol 3-kinase/Akt in adipose and muscle cells. However, it is ... Cited by 87 - Related articles - All 7 versions
- ►cell.com SH Um, D D'Alessio, G Thomas - Cell metabolism, 2006 - Elsevier Nutrient overload leads to obesity, insulin resistance, and often type 2 diabetes. Whereas increased
fat intake is commonly cited as the major factor in diet-induced dysmetabolic states, increased
protein consumption also contributes, through elevated circulating amino acids. Recent ... Cited by 89 - Related articles - All 9 versions
M Krebs, M Krssak, E Bernroider, C Anderwald, A … - Diabetes, 2002 - Am Diabetes Assoc Plasma concentrations of amino acids are frequently elevated in insulin-resistant states, and
a protein-enriched diet can impair glucose metabolism. This study examined effects of
short-term plasma amino acid (AA) elevation on whole-body glucose disposal and ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►jbc.org F Tremblay, A Marette - Journal of Biological Chemistry, 2001 - ASBMB Amino acids have emerged as potent modulators of the mTOR/p70 S6 kinase pathway. The involvement
of this pathway in the regulation of insulin-stimulated glucose transport was investigated in the
present study. Acute exposure (1 h) to a balanced mixture of amino acids reduced insulin- ... Cited by 154 - Related articles - BL Direct - All 3 versions
- ►endojournals.org F Tremblay, AM Gagnon, A Veilleux, A Sorisky, A … - Endocrinology, 2005 - Endocrine Soc The mammalian target of rapamycin (mTOR) pathway has recently emerged as a chronic modulator
of insulin-mediated glucose metabolism. In this study, we evaluated the involvement of this pathway
in the acute regulation of insulin action in both 3T3-L1 and human adipocytes. Insulin ... Cited by 64 - Related articles - All 3 versions
M Ueno, JBC Carvalheira, RC Tambascia, RMN … - Diabetologia, 2005 - Springer Abstract Aim/hypothesis: Several epidemiological stud- ies have suggested an association between
chronic hyper- insulinaemia and insulin resistance. However, the causality of this relationship
remains uncertain. Methods: We per- formed chronic hyperinsulinaemic–euglycaemic ... Cited by 53 - Related articles - All 4 versions
- ►nih.gov A Tzatsos, KV Kandror - Molecular and cellular biology, 2006 - Am Soc Microbiol Nutritional excess and/or obesity represent well-known predisposition factors for the development
of non-insulin-dependent diabetes mellitus (NIDDM). However, molecular links between obesity
and NIDDM are only beginning to emerge. Here, we demonstrate that nutrients suppress ... Cited by 98 - Related articles - BL Direct - All 9 versions
M Krebs, A Brehm, M Krssak, C Anderwald, E … - Diabetologia, 2003 - Springer Corresponding author: Dr. M. Roden, Division of Endocri- nology and Metabolism, Department
of Internal Medicine III, University of Vienna Medical School, Währinger Gürtel 18–20, 1090
Vienna, Austria E-mail: michael.roden@akh-wien.ac.at Abbreviations: AA, amino acids; ... Cited by 27 - Related articles - BL Direct - All 4 versions
SH Um, F Frigerio, M Watanabe, F Picard, M Joaquin, … - Nature, 2004 - chem.uwec.edu 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
2Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ ULP, and Institut
Clinique de la Souris, Génopole Strasbourg, 67404 Illkirch, France 3Novartis Pharma AG, ... Cited by 386 - Related articles - View as HTML - BL Direct - All 9 versions
