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Scholar Results 1 - 10 of about 101 related to Mordes: LEW. 1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental.... (0.13 sec) 

LEW. 1WR1 rats develop autoimmune diabetes spontaneously and in response to …


JP Mordes, DL Guberski, JH Leif, BA Woda, JF … - Diabetes, 2005 - Am Diabetes Assoc
We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility
complex congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1 u/u/a ) occurs with
a cumulative frequency of ∼2% at a median age of 59 days. The disease is characterized ...
Cited by 10 - Related articles - BL Direct - All 6 versions

The rat diabetes susceptibility locus Iddm4 and at least one additional gene are …

- diabetesjournals.org
EP Blankenhorn, L Rodemich, C Martin-Fernandez, J … - Diabetes, 2005 - Am Diabetes Assoc
BBDR rats develop autoimmune diabetes only after challenge with environmental
perturbants. These perturbants include polyinosinic:polycytidylic acid (poly I:C, a ligand of
toll-like receptor 3), agents that deplete regulatory T-cell (Treg) populations, and a non–β- ...
Cited by 12 - Related articles - All 6 versions

T Cell Immunity to Type II Collagen in the Biobreeding Rat: The Identification and …

- jimmunol.org
MA Cremer, XJ Ye, LK Myers, DD Brand, EF … - The Journal of …, 2004 - Am Assoc Immnol
Susceptibility to experimental collagen-induced arthritis in rodents is dependent on MHC class
II elements to bind peptides from the type II collagen (CII) molecule. Although a substantial body
of data has been reported in mice defining these peptide Ags, little has been reported in ...
Cited by 2 - Related articles - All 4 versions

PolyI: C induction of diabetes is controlled by Iddm4 in rats with a full regulatory T …


L HORNUM, D LUNDSGAARD, H … - ANNALS-NEW YORK …, 2007 - interscience.wiley.com
Abstract : The Iddm4 gene controls diabetes in rats depleted of regulatory T cells (T reg ) and
immune-activated via treatment with the toll-like receptor 3 (TLR-3) ligand, polyI:C. Both
diabetes-resistant (BBDR) and diabetes-prone (BBDP) BB rats carry dominant permissive ...
Cited by 3 - Related articles - BL Direct - All 4 versions

Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in …


D Wedekind, H Weiss, A Jörns, S Lenzen, M … - …, 2005 - informahealthcare.com
The importance of the cellular immune system for the development of T1DM in the
LEW.1AR1-iddm rat was investigated by use of polyinosinic-polycytidylic acid (Poly I:C) and
by adoptive transfer of concanavalin A (Con A) activated lymphocytes from diabetic LEW. ...
Cited by 3 - Related articles - All 7 versions

[PDF] Invasion of the killer B's in type 1 diabetes


PA Silveira, DV Serreze, ST Grey - Front. Biosci, 2007 - bioscience.org
1. Abstract 2. .Introduction 3. An important role for B cells in T1D 4. What is the role of B cells
in T1D? 4.1. B cells function as a diabetogenic APC 4.2. Specific Ig-mediated antigen capture
allows B-cells to be preferential diabetogenic APC 5. Do B-cell tolerance defects underlie ...
Cited by 4 - Related articles - View as HTML - All 2 versions

[PDF] Role of peritoneal macrophages in cytomegalovirus-induced acceleration of …


JAN ROZING - Clinical & Developmental Immunology, 2003 - downloads.hindawi.com
Page 1. Role of Peritoneal Macrophages in Cytomegalovirus-induced Acceleration of
Autoimmune Diabetes in BB-rats JAN-LUUK HILLEBRANDSa,*, NIENKE VAN DER WERFa,*,
FLIP A. KLATTERa, CATHRIEN A. BRUGGEMANb and JAN ROZINGa,† ...
Cited by 5 - Related articles - View as HTML - BL Direct - All 11 versions

[PDF] Coxsackievirus Infections and NOD Mice


S TRACY, KM DRESCHER - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2007 - unmc.edu
ABSTRACT: Human enteroviruses (HEVs) like the group B coxsack- ieviruses (CVBs) are prime
candidates for infectious, environmental causes of human type 1 diabetes (T1D). Non-obese
diabetic (NOD) fe- male mice are well protected from T1D onset if inoculated with CVB ...
Cited by 5 - Related articles - View as HTML - BL Direct - All 8 versions

Infections that induce autoimmune diabetes in BBDR rats modulate CD4+ CD25+ T …

- jimmunol.org
D Zipris, JL Hillebrands, RM Welsh, J Rozing … - The Journal of …, 2003 - Am Assoc Immnol
Viruses are believed to contribute to the pathogenesis of autoimmune type 1A diabetes in
humans. This pathogenic process can be modeled in the BBDR rat, which develops pancreatic
insulitis and type 1A-like diabetes after infection with Kilham's rat virus (RV). The ...
Cited by 32 - Related articles - BL Direct - All 6 versions

Transient diabetes following chicken pox.


MV Jali, PS Shankar - The Journal of the Association of Physicians of …, 1990 - ncbi.nlm.nih.gov
1: J Assoc Physicians India. 1990 Sep;38(9):663-4. Transient diabetes following chicken pox.
Jali MV, Shankar PS. Dr NMK Hospital, Hafer Al-Baten. The paper describes two individuals
presenting with acute insulin dependent diabetes mellitus for a brief and transient period. ...
Cited by 7 - Related articles


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