PPL Lam, YM Leung, L Sheu, J Ellis, RG Tsushima, LR … - Diabetes, 2005 - Am Diabetes Assoc Soluble N-ethylmaleimide–sensitive factor (NSF) attachment protein receptor (SNARE) protein
syntaxin-1A (STX-1A) plays a role not only in exocytosis, but also binds and regulates Ca 2+
and K + (voltage-gated K + and ATP-sensitive K + channels) to influence the sequence of ... Cited by 17 - Related articles - BL Direct - All 7 versions
R Alemzadeh, C Fledelius, T Bodvarsdottir, J Sturis - Metabolism, 2004 - Elsevier Chronic attenuation of hyperinsulinemia by diazoxide (DZ), a K-adenosine triphosphate
(ATP) channel opener and an inhibitor of glucose-mediated insulin secretion, improved glucose
tolerance and lipid profile and decreased the rate of weight gain in obese Zucker rats. To ... Cited by 12 - Related articles - All 8 versions
M Matsuda, F Kawasaki, Y Mikami, Y Takeuchi, M … - European journal of …, 2002 - Elsevier In this study, we attempted to demonstrate the possibility of rescuing beta-cell exhaustion by
chronic intervention with an ATP-sensitive K + channel opener, diazoxide, which reduces the
stress of insulin secretion, using rats with streptozotocin-induced diabetes. Three groups ... Cited by 16 - Related articles - All 4 versions
Y Kang, YM Leung, JE Manning-Fox, F Xia, H Xie, L … - Journal of Biological …, 2004 - ASBMB ATP-sensitive potassium (K ATP ) channels couple the metabolic status of the cell to its membrane
potential to regulate a number of cell actions, including secretion (neurons and neuroendocrine
cells) and muscle contractility (skeletal, cardiac, and vascular smooth muscle). K ATP ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►physiology.org H Yoshikawa, Z Ma, A Bjorklund, V … - American Journal of …, 2004 - Am Physiological Soc Prolonged periods of " -cell rest" exert beneficial effects on insulin secretion from pancreatic islets
subjected to a high-glucose environment. Here, we tested for effects of short-term intermittent
rest achieved by diazoxide. Rat islets were cultured for 48 h with 27 mmol/l glucose ... Cited by 20 - Related articles - BL Direct - All 5 versions
M Trus, O Wiser, MC Goodnough, D Atlas - Neuroscience, 2001 - Elsevier Syntaxin 1A has a pronounced inhibitory effect on the activation kinetics and current amplitude
of voltage-gated Ca 2+ channels. This study explores the molecular basis of syntaxin interaction
with N- and Lc-type Ca 2+ channels by way of functional assays of channel gating in a ... Cited by 19 - Related articles - BL Direct - All 4 versions
JB Hansen - Current medicinal chemistry, 2006 - ingentaconnect.com Openers of beta cell K ATP channels (Kir6.2/SUR1), which reduce insulin release to induce beta
cell rest, have been proposed for treatment and prevention of metabolic diseases [8,9,10,11]
. These compounds protect beta cells against the toxic effects of high glucose [13,14,15], ... Cited by 21 - Related articles - BL Direct - All 4 versions
YA Hosokawa, JL Leahy - Diabetes, 1997 - Am Diabetes Assoc The overworked-beta-cell hypothesis proposes that lowered glucose-potentiated insulin secretory
responses in diabetes are secondary to hyperstimulated insulin secretion and depletion of the
beta-cell insulin stores. We tested this hypothesis in normal rats using a 48-h infusion of ... Cited by 21 - Related articles - BL Direct - All 7 versions
- ►jbc.org N Cui, Y Kang, Y He, YM Leung, H Xie, EA Pasyk, X … - Journal of Biological …, 2004 - ASBMB The ATP-sensitive potassium (K ATP ) channel in pancreatic islet beta cells consists of four
pore-forming (Kir6.2) subunits and four regulatory sulfonylurea receptor (SUR1) subunits. In
beta cells, the K ATP channel links intracellular metabolism to the dynamic regulation of ... Cited by 20 - Related articles - All 4 versions
PTBB Stephane, BMDPW Marie, HAFSS … - Journal of Medicinal …, 2003 - 万方数据资源系统 3-(Alkylamino)-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides were synthesized, and their activity
on rat-insulin-secreting cells and rat aorta rings was compared to that of the K_(ATP) channel
activators diazoxide and pinacidil. Structure-activity relationships indicated that an ... Cited by 21 - Related articles - BL Direct - All 4 versions
