- ►shouxi.net C Kjørholt, MC Åkerfeldt, TJ Biden, DR … - Diabetes, 2005 - Am Diabetes Assoc The β-cell is a highly specialized cell with a unique differentiation that
optimizes glucose-induced insulin secretion (GIIS). Here, we evaluated changes
in gene expression that accompany β-cell dysfunction in the db/db mouse ... Cited by 27 - Related articles - BL Direct - All 6 versions
- ►physiology.org MZ Khaldi, Y Guiot, P Gilon, JC Henquin, JC … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Chronic hyperglycemia has been shown to induce either a lack of response or an
increased sensitivity to glucose in pancreatic -cells. We reinvestigated this
controversial issue in a single experimental model by culturing rat islets ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►physiology.org MZ Khaldi, H Elouil, Y Guiot, JC Henquin, JC … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc We previously showed that the stimulation of heme oxygenase-1 expression by high
glucose and hydrogen peroxide (H 2 O 2 ) in cultured rat islets is prevented by
antioxidants and suggested that this effect of high glucose results from an ... Cited by 3 - Related articles - BL Direct - All 3 versions
- ►endojournals.org M Dubois, P Vacher, B Roger, D Huyghe, B … - Endocrinology, 2007 - Endocrine Soc Prolonged exposure of ß-cells to high glucose (glucotoxicity) diminishes
insulin secretion in response to glucose and has been linked to altered
generation of metabolism-secretion coupling factors. We have investigated ... Cited by 23 - Related articles - BL Direct - All 3 versions
Y Moritoh, K Takeuchi, T Asakawa, O Kataoka … - European journal of pharmacology, 2008 - Elsevier Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control in patients
with type 2 diabetes by increasing plasma active glucagon-like peptide-1 (GLP-1)
and glucose-dependent insulinotropic polypeptide levels. However, the ... Cited by 10 - Related articles - All 4 versions
B Lee, L Shi, DB Kassel, T Asakawa, K … - European Journal of Pharmacology, 2008 - Elsevier The aim of the present research was to characterize the pharmacokinetic,
pharmacodynamic, and efficacy profiles of alogliptin, a novel
quinazolinone-based dipeptidyl peptidase-4 (DPP-4) inhibitor. Alogliptin ... Cited by 12 - Related articles - All 3 versions
H Elouil, AK Cardozo, DL Eizirik, JC Henquin … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Hyperglycaemia and the pro- inflammatory cytokine
IL-1β induce similar alterations of beta cell gene expression, including
up-regulation of c-Myc and haeme-oxygenase 1. These effects of ... Cited by 25 - Related articles - BL Direct - All 6 versions
E Ito, S Ozawa, K Takahashi, T Tanaka, H … - Biochemical and Biophysical Research …, 2004 - Elsevier Peroxisome proliferator-activated receptor-γ (PPAR-γ) regulates several
cellular functions, but its physiological role in pancreatic islet cells remains
to be investigated. In this study, we confirmed the presence of PPAR-γ in ... Cited by 26 - Related articles - All 4 versions
- ►nih.gov [PDF] GL Robinson, SR Cordle, E Henderson, PA … - Molecular and Cellular Biology, 1994 - Am Soc Microbiol Page 1. MOLECULAR AND CELLULAR BIOLOGY, Oct. 1994, p. 6704-6714 0270-7306/94/
$04.00+0 Copyright X 1994, American Society for Microbiology ... Cited by 16 - Related articles - BL Direct - All 6 versions
[CITATION] Van de CM, and Pipeleers D
GA Martens, Y Cai, S Hinke, G Stange - … in metabolically responsive pancreatic beta cells. J …, 2005 Cited by 2 - Related articles
