- ►diabetesjournals.org S Prudente, ML Hribal, E Flex, F Turchi, E Morini, S De … - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance plays a major role in dyslipidemia, cardiovascular disease, and type 2
diabetes. TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has
been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of ... Cited by 26 - Related articles - BL Direct - All 5 versions
H Okamoto, E Latres, R Liu, K Thabet, A Murphy, D … - Diabetes, 2007 - Am Diabetes Assoc Trb3, a mammalian homolog of Drosophila tribbles, was proposed as a suppressor of Akt
activity, predominantly in conditions of fasting and diabetes. Given these prior studies, we sought
to determine whether Trb3 plays a major role in modulating hepatic insulin sensitivity. To ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►jbc.org R Matsushima, N Harada, NJG Webster, YM … - Journal of Biological …, 2006 - ASBMB Insulin and nutrients activate hepatic p70 S6 kinase (S6K1) to regulate protein synthesis.
Paradoxically, activation of S6K1 also leads to the development of insulin resistance. In this
study, we investigated the effect of TRB3, which acts as an endogenous inhibitor of Akt, ... Cited by 29 - Related articles - All 7 versions
S Kato, K Du - Biochemical and Biophysical Research …, 2007 - Elsevier TRB3 is a member of TRB protein family characterized by containing a variant kinase domain
without enzymatic activity. Interacting with Ser/Thr protein kinases Akt, TRB3 impairs Akt activation
induced by growth factors and insulin. In this study we have examined the potential role of ... Cited by 19 - Related articles - All 5 versions
PB Iynedjian - Biochemical Journal, 2005 - pubmedcentral.nih.gov The protein TRB3 (tribbles 3), also called NIPK (neuronal cell death-inducible protein
kinase), was recently identified as a protein–protein interaction partner and an inhibitor of PKB
(protein kinase B). To explore the hypothesis that TRB3/NIPK might act as a negative ... Cited by 28 - Related articles - All 8 versions
- ►ahajournals.org F Andreozzi, G Formoso, S Prudente, ML … - … , and vascular biology, 2008 - Am Heart Assoc From the Department of Experimental and Clinical Medicine (FA, MLH, GS), University Magna
Græcia of Catanzaro, Catanzaro, Italy; Department of Medicine and Aging Sciences (GF,
AC), University "G. d'Annunzio", Aging Research Center, Ce.SI, "G. d'Annunzio" University ... Cited by 6 - Related articles - All 8 versions
- ►jbc.org L He, FA Simmen, HM Mehendale, MJJ Ronis, TM … - Journal of Biological …, 2006 - ASBMB Chronic and excessive alcohol consumption is an important and modifiable risk factor for type
2 diabetes. We previously reported elevations in hepatic Class 1 alcohol dehydrogenase
(ADH) expression in ethanol-fed rats correspondent with reduced levels of mature, ... Cited by 40 - Related articles - BL Direct - All 16 versions
R Schwarzer, S Dames, D Tondera, A Klippel, J … - Cellular signalling, 2006 - Elsevier We have identified TRB3, a human homologue of Drosophila tribbles, as a novel transcriptional
target of phosphatidylinositol (PI) 3-kinase. TRB3 expression is remarkably reduced in prostate
cancer PC-3 cells after inhibition of PI 3-kinase. TRB3 expression is furthermore ... Cited by 24 - Related articles - All 4 versions
- ►salk.edu [PDF] L Qi, JE Heredia, JY Altarejos, R Screaton, N … - Science's …, 2006 - stke.sciencemag.org Abstract: During fasting, increased concentrations of circulating catecholamines promote the
mobilization of lipid stores from adipose tissue in part by phosphorylating and inactivating
acetyl–coenzyme A carboxylase (ACC), the rate-limiting enzyme in fatty acid synthesis. ... Cited by 55 - Related articles - BL Direct - All 15 versions
