MY Donath, JA Ehses, K Maedler, DM … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to
the pathophysiology of type 2 diabetes. Opinions diverge regarding the relative
contribution of a decrease in β-cell mass versus an intrinsic defect in ... Cited by 85 - Related articles - BL Direct - All 6 versions
MY Donath, JA Ehses - Pancreatic Beta Cell in Health and Disease, 2007 - Springer Summary. A decrease in both mass and secretory function of insulin produc- ing
beta cells contribute to the pathophysiology of type 1 and type 2 diabetes. In
this chapter, we review the evidence that glucose, inflammation, dyslipid- ... Related articles - All 2 versions
K Maedler, P Sergeev, JA Ehses, Z Mathe, D … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences High concentrations of glucose induce β cell production of IL-1β, leading to
impaired β cell function and apoptosis in human pancreatic islets. IL-1
receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1β ... Cited by 82 - Related articles - BL Direct - All 13 versions
MY Donath, DM Schumann, M Faulenbach, H … - Diabetes Care, 2008 - Am Diabetes Assoc Inflammation is defined as the local response to tissue injury. It is
characterized by immune cell invasion and local release of cytokines and
chemokines and is sometimes accompanied by functional or structural damage ... Cited by 20 - Related articles - BL Direct - All 4 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or
relative insu- lin insufficiency in both conditions. In this For Debate, we ... Cited by 122 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org K Maedler, GA Spinas, R Lehmann, P Sergeev … - Diabetes, 2001 - Am Diabetes Assoc In autoimmune type 1 diabetes, Fas–to–Fas-ligand (FasL) interaction may
represent one of the essential pro-apoptotic pathways leading to a loss of
pancreatic ß-cells. In the advanced stages of type 2 diabetes, a decline ... Cited by 195 - Related articles - BL Direct - All 5 versions
[CITATION] Gene expression profile in the pancreatic islets of Goto-Kakizaki (GK) rats with repeated …
- ►diabetesjournals.org N Welsh, M Cnop, I Kharroubi, M Bugliani, R … - Diabetes, 2005 - Am Diabetes Assoc Different degrees of β-cell failure and apoptosis are present in type 1 and
type 2 diabetes. It has been recently suggested that high glucose–induced
β-cell apoptosis in type 2 diabetes shares a final common pathway with ... Cited by 40 - Related articles - BL Direct - All 6 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
- ►pnas.org K Maedler, A Fontana, F Ris, P Sergeev, C … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences Type 2 diabetes mellitus results from an inadequate adaptation of the functional
pancreatic β cell mass in the face of insulin resistance. Changes in the
concentration of glucose play an essential role in the regulation of β ... Cited by 96 - Related articles - BL Direct - All 11 versions
