OP Kristiansen, T Mandrup-Poulsen - Diabetes, 2005 - Am Diabetes Assoc Inflammatory mechanisms play a key role in the pathogenesis of type 1 diabetes. Individuals
who progress to type 2 diabetes display features of low-grade inflammation years in advance
of disease onset. This low-grade inflammation has been proposed to be involved in the ... Cited by 72 - Related articles - BL Direct - All 5 versions
AL Carey, MA Febbraio - Diabetologia, 2004 - Springer With the discovery of a number of immunomodulato- ry cytokines 15 to 20 years ago [1, 2] came
the obser- vation that so-called “inflammatory cytokines” such as TNFα, IL-6, IL-1α and IL-1β
were capable of ex- erting effects on the body's major metabolic tissues: skeletal muscle, ... Cited by 50 - Related articles - BL Direct - All 3 versions
- ►physiology.org GB Di Gregorio, L Hensley, T Lu, G … - American Journal of …, 2004 - Am Physiological Soc Obesity-related insulin resistance may be caused by adipokines such as IL-6, which is known
to be elevated with the insulin resistance syndrome. A previous study reported that IL-6 knockout
mice (IL-6 –/– ) developed maturity onset obesity, with disturbed carbohydrate and lipid ... Cited by 51 - Related articles - All 3 versions
AL Carey, GR Steinberg, SL Macaulay, WG Thomas, … - Diabetes, 2006 - Am Diabetes Assoc Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding
the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases
glucose disposal without affecting the complete suppression of endogenous glucose ... Cited by 99 - Related articles - BL Direct - All 6 versions
- ►endojournals.org L Al-Khalili, K Bouzakri, S Glund, F Lonnqvist, … - Molecular …, 2006 - Endocrine Soc We identified signaling pathways by which IL-6 regulates skeletal muscle differentiation and
metabolism. Primary human skeletal muscle cells were exposed to IL-6 (25 ng/ml either acutely
or for several days), and small interfering RNA gene silencing was applied to measure ... Cited by 49 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org NB Ruderman, C Keller, AM Richard, AK Saha, Z Luo, … - Diabetes, 2006 - Am Diabetes Assoc Interleukin (IL)-6 is a pleiotropic hormone that has both proinflammatory and anti-inflammatory
actions. AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme that among its other
actions responds to decreases in cellular energy state by enhancing processes that ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] KA Wadt, CM Larsen, HU Andersen, K Nielsen, AE … - Diabetes, 1998 - Am Diabetes Assoc Proinflammatory cytokines are implicated as eff ector molecules in the pathogenesis of
IDDM. Interleukin-6 (IL-6) alone or in combination with IL-1 inhibits glu- cose-stimulated insulin
release from isolated rat pan- creatic islets by unknown mechanisms. Here we inves- ... Cited by 28 - Related articles - All 5 versions
V Rotter Sopasakis, BM Larsson, A Johansson, A … - Diabetologia, 2004 - Springer Aims/hypothesis. Interleukin-6 has been implicated in the insulin resistance associated with obesity
and im- paired glucose tolerance. Previous studies in vitro have shown that IL-6 rapidly (1–2
h) impairs cellular insulin signalling and action through an increased ex- pression of ... Cited by 31 - Related articles - All 3 versions
- ►diabetesjournals.org HJ Kim, T Higashimori, SY Park, H Choi, J Dong, YJ … - Diabetes, 2004 - Am Diabetes Assoc The circulating level of the inflammatory cytokine interleukin (IL)-6 is elevated in various
insulin-resistant states including type 2 diabetes, obesity, cancer, and HIV-associated
lipodystrophy. To determine the role of IL-6 in the development of insulin resistance, we ... Cited by 166 - Related articles - BL Direct - All 4 versions
C Lagathu, JP Bastard, M Auclair, M Maachi, J … - … and Biophysical Research …, 2003 - Elsevier IL-6 has emerged as an important cytokine upregulated in states of insulin resistance such as
type 2 diabetes. We evaluated the chronic effect of IL-6 on insulin signaling in 3T3-F442A and
3T3-L1 adipocytes. First, cells responded to a chronic treatment with IL-6 by initiating an ... Cited by 141 - Related articles - All 5 versions
